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产品信息
PA5-115679
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human NUP214(Accession P35658), corresponding to amino acid residues P1974-F2024.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2900314
产品详细信息
Antibody detects endogenous levels of total NUP214.
靶标信息
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms.
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生物信息学
蛋白别名: 214 kDa nucleoporin; CAN protein, putative oncogene; Nuclear pore complex protein Nup214; nucleoporin 214kDa; Nucleoporin Nup214; Protein CAN
基因别名: BC039282; CAIN; CAN; D2H9S46E; KIAA0023; NUP214
UniProt ID: (Human) P35658, (Mouse) Q80U93
Entrez Gene ID: (Human) 8021, (Mouse) 227720
RNA export from nucleus
mRNA export from nucleus
tRNA export from nucleus
protein import into nucleus
protein export from nucleus
mitotic nuclear envelope disassembly
regulation of glucose transport
viral process
protein sumoylation
viral transcription
gene silencing by RNA
regulation of mRNA stability
regulation of cell cycle
intracellular transport of virus
regulation of cellular response to heat
transport
protein transport
mRNA transport
