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产品信息
MA5-32647
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JM59-11
抗原
Synthetic peptide within Human NUR77 aa 10-49
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% Glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2809924
产品详细信息
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
NR4A1 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. NGFI-B-alpha is expressed in brain, adrenal, thyroid, liver, testis, ovary, thymus, muscle, lung and prostate. Its expression is induced in response to various stress stimuli and growth factors. The encoded protein acts as a nuclear transcription factor involved in mediating apoptotic signaling in thymocytes and tumor cells, as well as having a role in signaling in the hypothalamic-pituitary axis. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Three transcript variants encoding two distinct isoforms have been identified for this NR4A1. Variant (3), also known as TRC beta, contains multiple differences compared to variant 1. The resulting isoform b contains a shorter and distinct C-terminus compared to isoform a. RXR has been shown to be a partner for NR4A1.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Early response protein NAK1; growth factor-inducible nuclear protein N10; hormone receptor; immediate early gene transcription factor NGFI-B; MGC9485; nerve growth factor IB nuclear receptor variant 1; nerve growth factor induced protein I-B; Nerve growth factor-induced protein I-B; NGFI-B; Nuclear hormone receptor NUR/77; Nuclear protein N10; Nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4, group A, member 1; Nuclear receptor subfamily 4immunitygroup A member 1; NUR77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; Orphan receptor tr3; ST-59; steroid receptor TR3; Testicular receptor 3; TR3 orphan receptor
基因别名: Gfrp; GFRP1; Hbr-1; Hbr1; HMR; N10; NAK-1; NAK1; NGFI-B; NGFIB; NP10; NR4A1; NUR77; TIS1; TR3
UniProt ID: (Human) P22736, (Rat) P22829, (Mouse) P12813
Entrez Gene ID: (Human) 3164, (Rat) 79240, (Mouse) 15370
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
sequence-specific DNA binding
protein heterodimerization activity
protein homodimerization activity
transcription factor activity, sequence-specific DNA binding
metal ion binding
C4 zinc finger nuclear receptor
positive regulation of endothelial cell proliferation
cell migration involved in sprouting angiogenesis
transcription initiation from RNA polymerase II promoter
signal transduction
intracellular receptor signaling pathway
endothelial cell chemotaxis
cellular response to vascular endothelial growth factor stimulus
steroid hormone mediated signaling pathway
cellular response to fibroblast growth factor stimulus
fat cell differentiation
negative regulation of cell cycle
positive regulation of transcription from RNA polymerase II promoter
regulation of type B pancreatic cell proliferation
cellular response to corticotropin-releasing hormone stimulus
transcription, DNA-templated
transcription from RNA polymerase II promoter
apoptotic process
skeletal muscle cell differentiation
positive regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of transcription, DNA-templated
cellular response to organic substance
regulation of transcription, DNA-templated
response to inorganic substance
