Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
图: 1 / 1
NaV1.7 (SCN9A) Antibody (ASC-008-GP200UL) in WB
Western blot analysis of rat DRG lysates: - 1. Guinea pig Anti-NaV1.7 (SCN9A) Antibody (#ASC-008-GP), (1:400). 2. Guinea pig Anti-NaV1.7 (SCN9A) Antibody , preincubated with Nav1.7/SCN9A Blocking Peptide (#BLP-SC008).Note:addition of 0.5% Tween-20 to the primary Antibody solution may strengthen the signal and lower background.
产品信息
ASC-008-GP200UL
产品规格
种属反应
Rat
宿主/亚型
Guinea pig
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)EFTSIGRSR IMGLSE, corresponding to amino acid residues 446-460 of rat NaV1.7, Intracellular loop between domains I and II
偶联物
形式
Lyophilized
浓度
0.85 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C, protected from the light, for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 X g 5 min).
靶标信息
Epithelial sodium channels are amiloride-sensitive members of the Degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (alpha, beta, and gamma) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator (CFTR) chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension (Liddels syndrome) and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism (PHA-1).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: hNE Na; KIAA1356; MED; NAC1; NAC2; NAC3; Nav1.1; Nav1.2; Nav1.3; Nav1.4; Nav1.5; Nav1.6; Nav1.8; Nav1.9; NE; NE NA; Peripheral sodium channel 1; PN1; SCN1; SCN10A; SCN11A; SCN12A; SCN1A; SCN2A1; SCN2A2; SCN3A; SCN4A; SCN5A; SCN8A; SNS2; Sodium channel protein type 9 subunit alpha; Sodium channel protein type IX subunit alpha; sodium channel, voltage-gated, type 9, alpha polypeptide; Voltage-gated sodium channel subunit alpha Nav1.7
基因别名: Nav1.7; PN1; Scn2a; Scn9a
UniProt ID: (Rat) O08562
Entrez Gene ID: (Rat) 78956
