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Nectin 2 Antibody (MA5-35822) in IHC (P)
Immunohistochemistry analysis of Nectin 2 in paraffin-embedded human placenta. Samples were incubated with Nectin 2 Monoclonal antibody (Product # MA5-35822) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
产品信息
MA5-35822
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC1665
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 410-538 of human Nectin 2/CD112 (ARC1665)
偶联物
形式
Liquid
浓度
0.42 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2849722
产品详细信息
Immunogen sequence: TPKAKLEAQE MPSQLFTLGA SEHSPLKTPY FDAGASCTEQ EMPRYHELPT LEERSGPLHP GATSLGSPIP VPPGPPAVED VSLDLEDEEG EEEEEYLDKI NPIYDALSYS SPSDSYQGKG FVMSRAMYV
靶标信息
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CD112; Herpes virus entry mediator B; Herpesvirus entry mediator B; herpesvirus entry protein B; hveB; mHveB; Murine herpes virus entry protein B; murine herpesvirus entry protein B; Nectin cell adhesion molecule 2; Nectin-2; Poliovirus receptor homolog; poliovirus receptor related 2; poliovirus receptor-like 2; poliovirus receptor-related 2 (herpesvirus entry mediator B); Poliovirus receptor-related protein 2; poliovirus sensitivity
基因别名: AI325026; AI987993; CD112; HVEB; MPH; nectin-2; NECTIN2; PRR2; Pvr; PVRL2; PVRR2; Pvs
UniProt ID: (Human) Q92692, (Mouse) P32507
Entrez Gene ID: (Human) 5819, (Rat) 308417, (Mouse) 19294
acrosome assembly
positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
positive regulation of immunoglobulin mediated immune response
cytoskeleton organization
homophilic cell adhesion via plasma membrane adhesion molecules
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
signal transduction
spermatid development
spermatid nucleus differentiation
cell recognition
fertilization
fusion of virus membrane with host plasma membrane
sperm mitochondrion organization
cell part morphogenesis
positive regulation of mast cell activation
adherens junction organization
susceptibility to natural killer cell mediated cytotoxicity
adhesion of symbiont to host
cilium organization
positive regulation of natural killer cell mediated cytotoxicity
regulation of viral entry into host cell
coreceptor-mediated virion attachment to host cell
regulation of immune response
establishment of mitochondrion localization
susceptibility to T cell mediated cytotoxicity
biological_process
cell adhesion
