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产品信息
PA5-23481
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A portion of amino acids 1-69 of mouse Neurog 3
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2540981
靶标信息
Neurog 3 protein contains one basic helix-loop-helix (bHLH) domain.It is both necessary and sufficient to induce endocrine islet cell differentiation from embryonic pancreatic progenitors. Not only does itinitiates endocrine cell differentiation, italso promotes islet cell maturation and maintains islet function. It is reported that Neurogenin 3 can redirect the differentiation of bipotential secretory progenitors to endocrine rather than goblet cell fate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: atonal homolog 5; Helix-loop-helix protein mATH-4B; mATH4B; Neurogenin 3 (Atonal protein homolog 5) (Helix-loop-helix protein mATH-4B) (MATH4B); Neurogenin-3; neurogenin3; NGN-3; Protein atonal homolog 5
基因别名: Ath4b; Atoh5; bHLHa7; Math4B; Neurog3; Ngn3
UniProt ID: (Mouse) P70661
Entrez Gene ID: (Mouse) 11925
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
transcription coactivator activity
protein binding
chromatin DNA binding
protein dimerization activity
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
nervous system development
cell differentiation
epithelial cell differentiation
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
regulation of dendrite morphogenesis
positive regulation of sequence-specific DNA binding transcription factor activity
transdifferentiation
