Invitrogen

Neuroligin 1 Polyclonal Antibody

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抗体检测数据 (2)

Neuroligin 1 Antibody in Immunocytochemistry (ICC/IF)

Neuroligin 1 Antibody in Immunocytochemistry (ICC/IF)

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Neuroligin 1 Antibody (PA5-142163) in ICC/IF

Immunocytochemistry-Immunofluorescence analysis of Neuroligin 1 in U2OS cells using Neuroligin 1 Polyclonal Antibody (Product # PA5-142163). Cells were fixed with paraformaldehyde, permeabilized with 0.15% Triton, and incubated with the primary antibody for 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing membrane/cytoplasmic staining. The nuclear stain is DAPI (blue). Negati... View More

Neuroligin 1 Antibody in Immunocytochemistry (ICC/IF)

Neuroligin 1 Antibody in Immunocytochemistry (ICC/IF)

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Neuroligin 1 Antibody in Immunocytochemistry (ICC/IF) — Immunocytochemistry-Immunofluorescence analysis of Neuroligin 1 in U2OS cells using Neuroligin 1 Polyclonal Antibody (Product # PA5-142163). Cells were fixed with paraformaldehyde, permeabilized with 0.15% Triton, and incubated with the primary antibody for 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing membrane/cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).

Neuroligin 1 Antibody in Immunocytochemistry (ICC/IF) — Immunocytochemistry-Immunofluorescence analysis of Neuroligin 1 in U251 cells using Neuroligin 1 Polyclonal Antibody (Product # PA5-142163). Cells were fixed with paraformaldehyde, permeabilized with 0.15% Triton, and incubated with the primary antibody for 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing membrane/cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL).

产品信息

PA5-142163

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1 µg/mL

-

免疫细胞化学 (ICC/IF)

10 µg/mL

-

产品规格

种属反应

Human

宿主/亚型

Goat / IgG

分类

Polyclonal

类型

Antibody

抗原

Peptide with sequence C-TAKQDDPKQQ.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Ammonium sulfate precipitation

保存液

TBS, pH 7.3, with 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2932821

产品详细信息

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:4,000.

靶标信息

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: MGC45115; Neuroligin-1; NLG 1

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基因别名: KIAA1070; NL1; NLGN1

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UniProt ID: (Human) Q8N2Q7

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Entrez Gene ID: (Human) 22871

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receptor activity PDZ domain binding neurexin family protein binding protein dimerization activity cell adhesion molecule binding carboxylic ester hydrolase activity scaffold protein binding cell adhesion molecule

参与通路

regulation of respiratory gaseous exchange by neurological system process protein targeting heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules neuron cell-cell adhesion nervous system development synapse assembly positive regulation of circadian sleep/wake cycle, wakefulness synaptic vesicle targeting calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules neuronal signal transduction neuron projection development positive regulation of synaptic transmission, GABAergic protein localization to synapse establishment of protein localization regulation of neuron differentiation rhythmic process cytoskeletal matrix organization at active zone protein homooligomerization protein heterotetramerization positive regulation of filopodium assembly positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic long-term synaptic potentiation positive regulation of dendritic spine development negative regulation of dendritic spine morphogenesis terminal button organization synaptic vesicle clustering postsynaptic membrane assembly presynaptic membrane assembly AMPA glutamate receptor clustering NMDA glutamate receptor clustering neurexin clustering involved in presynaptic membrane assembly postsynaptic density protein 95 clustering receptor localization to synapse positive regulation of ruffle assembly positive regulation of synaptic vesicle endocytosis positive regulation of protein localization to synapse positive regulation of intracellular signal transduction positive regulation of synaptic vesicle exocytosis regulation of N-methyl-D-aspartate selective glutamate receptor activity regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity positive regulation of excitatory postsynaptic potential positive regulation of synaptic vesicle clustering