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产品信息
MA5-33074
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
RM373
抗原
A peptide corresponding to the N-terminus of human TTF1 (Thyroid transcription factor 1) (Homeobox protein Nkx-2.1).
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Protein A
保存液
PBS with 1% BSA, 50% glycerol
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2810167
产品详细信息
Specificity: reacts to human TTF1 (Thyroid transcription factor 1) (Homeobox protein Nkx-2.1). It may also react to mouse and rat TTF1, as predicted by immunogen homology.^M
^M
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
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生物信息学
蛋白别名: Homeobox protein NK-2 homolog A; Homeobox protein Nkx-2.1; NK-2 homolog A; T/EBP; Thyroid nuclear factor 1; Thyroid transcription factor 1; Thyroid-specific enhancer-binding protein; TTF-1; TTF1
基因别名: BCH; BHC; NK-2; NKX2-1; NKX2.1; NKX2A; NMTC1; T/EBP; TEBP; TITF1; TTF-1; TTF1
UniProt ID: (Human) P43699
Entrez Gene ID: (Human) 7080
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region DNA binding
core promoter binding
intronic transcription regulatory region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
enzyme binding
transcription regulatory region DNA binding
intronic transcription regulatory region DNA binding
homeodomain transcription factor
negative regulation of transcription from RNA polymerase II promoter
neuron migration
regulation of blood volume by renin-angiotensin
transcription, DNA-templated
phospholipid metabolic process
axon guidance
brain development
endoderm development
locomotory behavior
feeding behavior
response to hormone
positive regulation of gene expression
negative regulation of epithelial to mesenchymal transition
globus pallidus development
hippocampus development
cerebral cortex cell migration
forebrain dorsal/ventral pattern formation
forebrain neuron fate commitment
cerebral cortex GABAergic interneuron differentiation
pituitary gland development
lung development
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
thyroid gland development
forebrain development
developmental induction
response to lipopolysaccharide
Leydig cell differentiation
hyperosmotic salinity response
positive regulation of circadian rhythm
response to ethanol
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
development of primary female sexual characteristics
rhythmic process
anatomical structure formation involved in morphogenesis
oligodendrocyte differentiation
lung saccule development
epithelial tube branching involved in lung morphogenesis
Clara cell differentiation
Type II pneumocyte differentiation
