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产品信息
PA5-111214
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2856624
产品详细信息
Immunogen sequence: PTEGSLAIEI FHQPKPDTEQ ASDSCLERFQ MDLFTVTLSQ VTFSLGSMVL EVTRPLSKWL KHPGALEKQM SRV
靶标信息
NODAL is an important TGF-beta family protein in cellular differentiation. While constitutively expressed in many developing tissues, NODAL is problematically associated with the differentiation and development of many cancers. The expression of NODAL is regulated by a Notch signaling pathway, which when disrupted contributes to the aggressive behavior of metastatic cancer cells, particularly in melanoma. The abundance of NODAL expression in melanoma can help determine the stage of cancer and metastatic type/progression when tested in IHC. NODAL interactions with Cripto also predispose toward tumor progression. Overexpression of NODAL is also associated with preeclamptic placenta.
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生物信息学
蛋白别名: MGC138230; Nodal homolog
基因别名: HTX5; NODAL
UniProt ID: (Human) Q96S42
Entrez Gene ID: (Human) 4838
negative regulation of transcription from RNA polymerase II promoter
trophectodermal cellular morphogenesis
neural fold formation
liver development
placenta development
embryonic placenta development
maternal placenta development
vasculature development
heart looping
inhibition of neuroepithelial cell differentiation
brain development
embryonic pattern specification
polarity specification of proximal/distal axis
regulation of gastrulation
positive regulation of vascular endothelial growth factor production
negative regulation of cell development
positive regulation of pathway-restricted SMAD protein phosphorylation
stem cell population maintenance
positive regulation of cell-cell adhesion
BMP signaling pathway
positive regulation of activin receptor signaling pathway
floor plate morphogenesis
endodermal cell differentiation
cell migration involved in gastrulation
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of angiogenesis
positive regulation of transcription from RNA polymerase II promoter
axial mesodermal cell fate specification
mesendoderm development
digestive tract morphogenesis
embryonic cranial skeleton morphogenesis
formation of anatomical boundary
positive regulation of epithelial cell proliferation
positive regulation of sequence-specific DNA binding transcription factor activity
embryonic process involved in female pregnancy
maternal process involved in parturition
positive regulation of SMAD protein import into nucleus
SMAD protein signal transduction
left lung morphogenesis
negative regulation of androgen receptor signaling pathway
epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification
positive regulation of ERK1 and ERK2 cascade
transforming growth factor beta receptor signaling pathway involved in primitive streak formation
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
negative regulation of trophoblast cell migration
negative regulation of chorionic trophoblast cell proliferation
regulation of stem cell population maintenance
