Target of Interest
Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
产品信息
PA5-50714
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to a region derived from internal residues of human natriuretic peptide receptor 2
偶联物
Unconjugated
形式
Liquid
浓度
0.9 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 40% glycerol
内含物
0.05% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2636166
产品详细信息
The antibody detects endogenous levels of total NPR2 protein.
靶标信息
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide, which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: ANP-B; ANPR-B; atrial natriuretic peptide B-type receptor; Atrial natriuretic peptide receptor 2; Atrial natriuretic peptide receptor type B; GC-B; guanylate cyclase 2B; Guanylate cyclase B; guanylyl cyclase-B; natriuretic peptide receptor B type; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); Nppb receptor; NPR-B
基因别名: AMDM; ANPb; ANPRB; cn; ECDM; GC-B; GC-B2; GC-B3; GUC2B; GUCY2B; mNPR-B; NPR2; NPRB; NPRBi; pwe; SNSK
UniProt ID: (Human) P20594, (Mouse) Q6VVW5
Entrez Gene ID: (Human) 4882, (Mouse) 230103
adenylate cyclase activity
guanylate cyclase activity
protein kinase activity
ATP binding
GTP binding
natriuretic peptide receptor activity
peptide hormone binding
hormone binding
identical protein binding
nucleotide binding
transferase activity, transferring phosphorus-containing groups
lyase activity
phosphorus-oxygen lyase activity
guanylate cyclase
ossification
cGMP biosynthetic process
protein phosphorylation
receptor guanylyl cyclase signaling pathway
regulation of blood pressure
intracellular signal transduction
single organism reproductive process
negative regulation of meiotic cell cycle
bone development
cellular response to granulocyte macrophage colony-stimulating factor stimulus
negative regulation of oocyte maturation
regulation of cardiac conduction
signal transduction
cyclic nucleotide biosynthetic process
