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Npr2 Antibody (MA5-37887) in WB
Western blot analysis of Npr2 in extracts of various cell lines. Samples were incubated with Npr2 Monoclonal antibody (Product # MA5-37887) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
MA5-37887
产品规格
种属反应
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
ARC2421
抗原
A synthetic peptide corresponding to a sequence within amino acids 800-900 of human ANPRB/NRP2 (P20594)
偶联物
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2897807
产品详细信息
Positive Samples: Mouse lung, Mouse spleen
Immunogen sequence: NLLLRMEQYA NNLEKLVEER TQAYLEEKRK AEALLYQILP HSVAEQLKRG ETVQAEAFDS VTIYFSDIVG FTALSAESTP MQVVTLLNDL YTCFDAIIDN F
靶标信息
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide, which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ANP-B; ANPR-B; Atrial natriuretic peptide receptor 2; Atrial natriuretic peptide receptor type B; GC-B; Guanylate cyclase B; guanylyl cyclase-B; natriuretic peptide receptor B type; Nppb receptor; NPR-B
基因别名: cn; GC-B; GC-B2; GC-B3; mNPR-B; Npr2; pwe
UniProt ID: (Mouse) Q6VVW5
Entrez Gene ID: (Mouse) 230103
nucleotide binding
guanylate cyclase activity
protein kinase activity
ATP binding
GTP binding
transferase activity, transferring phosphorus-containing groups
lyase activity
phosphorus-oxygen lyase activity
natriuretic peptide receptor activity
peptide hormone binding
hormone binding
identical protein binding
guanylate cyclase
ossification
cGMP biosynthetic process
protein phosphorylation
signal transduction
receptor guanylyl cyclase signaling pathway
cyclic nucleotide biosynthetic process
intracellular signal transduction
single organism reproductive process
negative regulation of meiotic cell cycle
bone development
negative regulation of oocyte maturation
