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产品信息
H00079991-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
OBFC1 (NP_079204.1, 1 a.a. approximately 368 a.a) full-length human protein.
偶联物
形式
Liquid
浓度
See Label
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Sequence of this protein is as follows: MQPGSSRCEE ETPSLLWGLD PVFLAFAKLY IRDILDMKES RQVPGVFLYN GHPIKQVDVL GTVIGVRERD AFYSYGVDDS TGVINCICWK KLNTESVSAA PSAARELSLT SQLKKLQETI EQKTKIEIGD TIRVRGSIRT YREEREIHAT AYYKVDDPVW NIQIARMLEL PTIYRKVYDQ PFHSSALEKE EALSNPGALD LPSLTSLLSE KAKEFLMENR VQSFYQQELE MVESLLSLAN QPVIHSACSD QVNFKKDTTS KAIHSIFKNA IQLLQEKGLV FQKDDGFDNL YYVTREDKDL HRKIHRIIQQ DCQKPNHMEK GCHFLHILAC ARLSIRPGLS EAVLQQVLEL LEDQSDIVST MEHYYTAF
靶标信息
OBFC1 is a component of the CST complex, a complex that binds to single-stranded DNA and is required to protect telomeres from DNA degradation. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. In addition to telomere protection, the CST complex has probably a more general role in DNA metabolism at non-telomeric sites.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: alpha accessory factor 44; CST complex subunit STN1; oligonucleotide/oligosaccharide-binding fold containing 1; Oligonucleotide/oligosaccharide-binding fold-containing protein 1; replication protein A 32 kDa subunit; Suppressor of cdc thirteen homolog
基因别名: AAF-44; AAF44; bA541N10.2; OBFC1; RPA-32; STN1
UniProt ID: (Human) Q9H668
Entrez Gene ID: (Human) 79991
telomere maintenance
telomere maintenance via telomere lengthening
telomere capping
positive regulation of telomere maintenance via telomerase
positive regulation of DNA replication
positive regulation of telomerase activity
negative regulation of telomerase activity
regulation of telomere maintenance via telomere lengthening
