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产品信息
PA5-60779
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.2 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2644937
产品详细信息
Immunogen sequence: GGGPHPPHTP SHPPSTRITR SQPNHTPAGP
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 87%.
靶标信息
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: hSSB1; LP3587; Nucleic acid-binding protein 2; oligonucleotide/oligosaccharide-binding fold containing 2B; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; single strand DNA-binding protein 1; Single-stranded DNA-binding protein 1; SOSS complex subunit B1; SOSS-B1
基因别名: hSSB1; LP3587; NABP2; OBFC2B; SOSS-B1; SSB1
UniProt ID: (Human) Q9BQ15
Entrez Gene ID: (Human) 79035
double-strand break repair via homologous recombination
DNA repair
cellular response to DNA damage stimulus
mitotic cell cycle checkpoint
response to ionizing radiation
snRNA transcription from RNA polymerase II promoter
regulation of telomerase activity
establishment of protein localization to telomere
positive regulation of telomere capping
