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产品信息
PA5-117043
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 148-427 of human OGDH (NP_0010039411)
偶联物
Unconjugated
形式
Liquid
浓度
0.25 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2901673
产品详细信息
Positive Samples: Mouse kidney, Mouse heart, Mouse brain, Rat kidney
Immunogen sequence: DPLGILDADL DSSVPADIIS STDKLGFYGL DESDLDKVFH LPTTTFIGGQ ESALPLREII RRLEMAYCQH IGVEFMFIND LEQCQWIRQK FETPGIMQFT NEEKRTLLAR LVRSTRFEEF LQRKWSSEKR FGLEGCEVLI PALKTIIDKS SENGVDYVIM GMPHRGRLNV LANVIRKELE QIFCQFDSKL EAADEGSGDV KYHLGMYHRR INRVTDRNIT LSLVANPSHL EAADPVVMGK TKAEQFYCGD TEGKKVRPRE RRARQIVKAP CSSMEFRSPT
靶标信息
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitocondrial matrix and uses thiamine pyrophosphate as a cofactor. A congential deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2-oxoglutarate dehydrogenase complex component E1; 2-oxoglutarate dehydrogenase E1 component, mitochondrial; 2-oxoglutarate dehydrogenase, mitochondrial; Alpha-ketoglutarate dehydrogenase; Alpha-KGDH-E1; E1o; OGDC-E1; oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide); oxoglutarate decarboxylase; oxoglutarate dehydrogenase (lipoamide); oxoglutarate dehydrogenase (succinyl-transferring); testicular tissue protein Li 131; Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase
基因别名: 2210403E04Rik; 2210412K19Rik; AA409584; AKGDH; d1401; E1k; Kiaa4192; mKIAA4192; OGDC; OGDH; Ogdhl
UniProt ID: (Human) Q02218, (Mouse) Q60597, (Rat) Q5XI78
Entrez Gene ID: (Human) 4967, (Mouse) 18293, (Rat) 360975
oxoglutarate dehydrogenase (succinyl-transferring) activity
thiamine pyrophosphate binding
heat shock protein binding
oxoglutarate dehydrogenase (NAD+) activity
metal ion binding
chaperone binding
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
dehydrogenase
generation of precursor metabolites and energy
glycolytic process
tricarboxylic acid cycle
2-oxoglutarate metabolic process
succinyl-CoA metabolic process
lysine catabolic process
NADH metabolic process
cerebellar cortex development
striatum development
hippocampus development
thalamus development
pyramidal neuron development
tangential migration from the subventricular zone to the olfactory bulb
glyoxylate metabolic process
olfactory bulb mitral cell layer development
metabolic process
oxidation-reduction process
