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产品信息
MA5-34661
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
JB44-39
抗原
Synthetic peptide within Human OGT aa 997-1,046
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
TBS, pH 7.4, with 40% glycerol, 0.05% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles, store in dark
运输条件
Wet ice
RRID
AB_2848569
产品详细信息
Positive Control: Hela, SiHa, A431, PC-3M, rat epididymis tissue, human liver tissue, human kidney tissue, mouse testis tissue.
靶标信息
This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ23071; MGC22921; o-glcnac transferase; O-GlcNAc transferase p110 subunit; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); O-linked N-acetylglucosamine transferase 110 kDa subunit; OGT; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase; uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase
基因别名: HINCUT-1; HRNT1; O-GLCNAC; OGT
UniProt ID: (Human) O15294
Entrez Gene ID: (Human) 8473
protein binding
phosphatidylinositol-3,4,5-trisphosphate binding
enzyme activator activity
transcription factor binding
acetylglucosaminyltransferase activity
protein N-acetylglucosaminyltransferase activity
protein domain specific binding
peptide binding
histone acetyltransferase activity (H4-K5 specific)
histone acetyltransferase activity (H4-K8 specific)
histone acetyltransferase activity (H4-K16 specific)
monosaccharide binding
protein O-GlcNAc transferase activity
protein modifying enzyme
positive regulation of protein phosphorylation
glucosamine metabolic process
regulation of glycolytic process
protein O-linked glycosylation
apoptotic process
signal transduction
response to nutrient
negative regulation of peptidyl-threonine phosphorylation
positive regulation of granulocyte differentiation
forebrain development
negative regulation of protein ubiquitination
response to insulin
cellular response to insulin stimulus
circadian regulation of gene expression
negative regulation of peptidyl-serine phosphorylation
regulation of Rac protein signal transduction
positive regulation of catalytic activity
histone H4-K5 acetylation
histone H4-K8 acetylation
histone H4-K16 acetylation
positive regulation of cell size
positive regulation of proteolysis
positive regulation of transcription from RNA polymerase II promoter
regulation of insulin receptor signaling pathway
phosphatidylinositol-mediated signaling
intracellular distribution of mitochondria
positive regulation of histone H3-K4 methylation
negative regulation of cell death
positive regulation of histone H3-K27 methylation
protein homotrimerization
protein heterotrimerization
cellular response to lipopolysaccharide
cellular response to retinoic acid
cellular response to glucose stimulus
histone H3-K4 trimethylation
negative regulation of protein targeting to membrane
regulation of gluconeogenesis involved in cellular glucose homeostasis
cellular response to toxic substance
negative regulation of cellular response to hypoxia
positive regulation of protein localization to nucleus
positive regulation of reactive oxygen species biosynthetic process
