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Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: DILLGFWPFG NALCKTVIAI DYYNMFTSTF TLTAMSVDRY VAICHPIRAL DVRTSSKAQA VNVAIWALAS VVGVPVAIMG SAQVEDEEIE CLVEIPTPQD YWG
The G-protein-coupled receptor (GPCR) superfamily is comprised of an estimated 600-1,000 members and is the largest known class of molecular targets with proven therapeutic value. The nociceptin receptor is a G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Kappa-type 3 opioid receptor; kappa3-related opioid receptor; KOR-3; LC132 Receptor-Like; Nociceptin receptor; nociceptin/orphanin FQ receptor; opiate receptor-like 1; OPPRL1; Orphanin FQ receptor
基因别名: KOR-3; NOCIR; NOP; NOPr; OOR; OPRL1; ORL1
UniProt ID: (Human) P41146
Entrez Gene ID: (Human) 4987
分子生物学功能:
G-protein coupled receptor
transmembrane signal receptor