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MA5-17024 reacts with ORC3 in human samples.
MA5-17024 has been successfully used in immunoprecipitation and Western blot applications.
The MA5-17024 immunogen is ORC3 (hsORC) produced in P3-x63Ag.8.653 cells.
Histone deacetylase 2 (HDAC2), or transcriptional regulator homolog RPD3 L1, is highly homologous to the yeast transcription factor RPD3 (reduced potassium dependency 3) gene. As in yeast, human HDA2 is likely to be involved in regulating chromatin structure during transcription. It has been implicated to associate with YY1, a mammalian zinc-finger transcription factor, which negatively regulates transcription by tethering RPD3 to DNA as a cofactor. This process is highly concerved from yeast to human.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: homolog of latheo, Drosophila; IMAGE50150; Origin recognition complex subunit 3; Origin recognition complex subunit Latheo; origin recognition complex, subunit 3 honolog; OTTHUMP00000040611; RP3-486L4.1
基因别名: LAT; LATHEO; ORC3; ORC3L
UniProt ID: (Human) Q9UBD5
Entrez Gene ID: (Human) 23595
分子生物学功能:
DNA metabolism protein
nucleic acid metabolism protein
replication origin binding protein