Invitrogen

OX40 Monoclonal Antibody (OX86)

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OX40 Antibody (MA1-70087) in Flow

Flow cytometric analysis using a CD134/OX-40 monoclonal antibody (Product # MA1-70087) at a 2.0 µg/10^6 cells dilution.

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产品信息

MA1-70087

应用

建议稀释比

已发表文章

流式细胞分析 (Flow)

1 µg/1 million cells

查看3篇已发表文章 3篇已发表文章

产品规格

种属反应

Mouse

已发表种属

Mouse

宿主/亚型

Rat / IgG1

分类

Monoclonal

类型

Antibody

克隆号

OX86

抗原

Recombinant mouse OX-40 antigen.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_1071227

产品详细信息

MA1-70087 detects CD134 in mouse samples.

MA1-70087 has been successfully used in flow cytometry procedures.

The MA1-70087 immunogen is recombinant mouse OX-40 antigen.

靶标信息

OX40 is a protein receptor found on the surface of T cells, a type of white blood cell that plays a crucial role in the immune system. When activated, OX40 promotes the proliferation and survival of T cells, leading to a stronger immune response against cancer cells and infectious agents. OX40 agonists, which are drugs that activate OX40, have shown promising results in preclinical and clinical studies as a potential immunotherapy for cancer. They can enhance the efficacy of other cancer treatments such as chemotherapy and checkpoint inhibitors, and may also have applications in autoimmune diseases and allergies.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

An Immunotherapeutic CD137 Agonist Releases Eomesodermin from ThPOK Repression in CD4 T Cells.

Journal of immunology (Baltimore, Md. : 1950)

Mittal P,Abblett R,Ryan JM,Hagymasi AT,Agyekum-Yamoah A,Svedova J,Reiner SL,St Rose MC,Hanley MP,Vella AT,Adler AJ

MA1-70087 was used in Flow cytometry/Cell sorting to indicate that CD137 costimulation, which is enabled by CD134, programs CD4 T cells to express Eomes through a novel mechanism that selectively releases Eomes from ThPOK repression.

Thu Feb 15 00:00:00 EST 2018

Increase of Frequency and Modulation of Phenotype of Regulatory T Cells by Atorvastatin Is Associated with Decreased Lung Inflammatory Cell Infiltration in a Murine Model of Acute Allergic Asthma.

Frontiers in immunology

Blanquiceth Y,Rodríguez-Perea AL,Tabares Guevara JH,Correa LA,Sánchez MD,Ramírez-Pineda JR,Velilla PA

MA170087 was used in flow cytometry to analyze the in vivo effect of atorvastatin on regulatory T cells and its association with the inflammatory process in a model of allergic asthma

Wed Nov 20 00:00:00 EST 2019

Depleting tumor-specific Tregs at a single site eradicates disseminated tumors.

The Journal of clinical investigation

Marabelle A,Kohrt H,Sagiv-Barfi I,Ajami B,Axtell RC,Zhou G,Rajapaksa R,Green MR,Torchia J,Brody J,Luong R,Rosenblum MD,Steinman L,Levitsky HI,Tse V,Levy R

MA1-70087 was used in Flow Cytometry to demonstrate that intratumoral coinjection of anti-CTLA-4 and anti-OX40 together with CpG depletes tumour-infiltrating regulatory T cells.