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Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: MGC20461; Oncostatin-M; OSM
基因别名: OSM
UniProt ID: (Human) P13725
Entrez Gene ID: (Human) 5008
分子生物学功能:
cytokine
interleukin superfamily
intercellular signal molecule