Invitrogen

Osteocalcin Polyclonal Antibody

Osteocalcin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Osteocalcin Antibody (PA5-11849) in IHC (P)

Immunohistochemistry analysis of Osteocalcin in formalin-fixed and paraffin-embedded human cancer tissue. Samples were incubated with Osteocalcin polyclonal antibody (Product # PA5-11849) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinom... View More

Osteocalcin Antibody in Western Blot (WB)

Osteocalcin Antibody in Immunocytochemistry (ICC/IF)

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产品信息

PA5-11849

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:2,000

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免疫组化（石蜡） (IHC (P))

1:50-1:100

免疫细胞化学 (ICC/IF)

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产品规格

种属反应

Human

已发表种属

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

KLH conjugated synthetic peptide between 2-32 amino acids from the N-terminal region of human Osteocalcin

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

2.0 mg/mL

纯化类型

Ammonium sulfate precipitation, Size-exclusion - Dialysis

保存液

PBS, pH 7.4

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2065046

靶标信息

Osteocalcin belongs to the osteocalcin/matrix Gla-protein family and constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

High glucose inhibits the osteogenic differentiation of periodontal ligament stem cells in periodontitis by activating endoplasmic reticulum stress.

Annals of translational medicine

Tan J,Zhou Y,Luo J,Wu X,Liu H,Wang W,Li Z,Zhong M,Wu L,Li X

PA5-11849 was used in Western Blot to suggest that high glucose inhibits the osteogenic differentiation ability of PDLSCs by activating ER stress, which ultimately exacerbates periodontitis.

Tue Feb 01 00:00:00 EST 2022

Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis.

Cell research

Wu J,Song D,Li Z,Guo B,Xiao Y,Liu W,Liang L,Feng C,Gao T,Chen Y,Li Y,Wang Z,Wen J,Yang S,Liu P,Wang L,Wang Y,Peng L,Stacey GN,Hu Z,Feng G,Li W,Huo Y,Jin R,Shyh-Chang N,Zhou Q,Wang L,Hu B,Dai H,Hao J

PA5-11849 was used in Immunocytochemistry-immunoflourescence to investigate the use of hESC-derived immunity-regulatory and matrix-regulatory cells in treating lung injury and fibrosis in mice.

Tue Sep 01 00:00:00 EDT 2020

A fully defined static suspension culture system for large-scale human embryonic stem cell production.

Cell death & disease

Li X,Ma R,Gu Q,Liang L,Wang L,Zhang Y,Wang X,Liu X,Li Z,Fang J,Wu J,Wang Y,Li W,Hu B,Wang L,Zhou Q,Hao J

Published figure using Osteocalcin polyclonal antibody (Product # PA5-11849) in Immunocytochemistry

Thu Aug 30 00:00:00 EDT 2018

生物信息学

蛋白别名: BGP; bone gamma-carboxyglutamate (gla) protein (osteocalcin); Bone Gla protein; Gamma-carboxyglutamic acid-containing protein; Osteocalcin; PMF1; RP11-54H19.5

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基因别名: BGLAP; BGP; OC; OCN

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UniProt ID: (Human) P02818

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Entrez Gene ID: (Human) 632

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功能

structural molecule activity calcium ion binding structural constituent of bone hydroxyapatite binding

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