Invitrogen

Osteocalcin Polyclonal Antibody

Osteocalcin Antibody in Immunocytochemistry (ICC/IF)

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Osteocalcin Antibody (PA5-96529) in ICC/IF

Immunofluorescence analysis of Osteocalcin in NIH/3T3 cells. Samples were incubated with Osteocalcin Polyclonal antibody (Product # PA5-96529) using a dilution of 1:200 (40x lens). Blue: DAPI for nuclear staining.

Osteocalcin Antibody in Western Blot (WB)

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产品信息

PA5-96529

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化（石蜡） (IHC (P))

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免疫细胞化学 (ICC/IF)

1:50-1:200

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酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Osteocalcin (BGLAP) (NP_9546421)

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20° C, Avoid Freeze/Thaw Cycles

运输条件

Wet ice

RRID

AB_2808331

产品详细信息

Immunogen sequence: MRALTLLALL ALAALCIAGQ AGAKPSGAES SKGAAFVSKQ EGSEVVKRPR RYLYQWLGAP VPYPDPLEPR REVCELNPDC DELADHIGFQ EAYRRFYGPV

靶标信息

Osteocalcin belongs to the osteocalcin/matrix Gla-protein family and constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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PA5-96529 was used in Immunocytochemistry to show that the magnetic magnesium-loaded scaffold, under the action of SMF, can accelerate the inflow of Mg2+ from surrounding microenvironment, which improved cellular activities, osteogenesis-related gene expression (ALP, Runx2, OCN, and OPN), and mineralization.

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3D-printed NIR-responsive shape memory polyurethane/magnesium scaffolds with tight-contact for robust bone regeneration.

Bioactive materials

Zhang Y,Li C,Zhang W,Deng J,Nie Y,Du X,Qin L,Lai Y

PA5-96529 was used in Immunohistochemistry (Paraffin) to report a near-infrared-responsive and tight-contacting scaffold that comprises of shape memory polyurethane (SMPU) as the thermal-responsive matrix and magnesium (Mg) as the photothermal and bioactive component, which fabricated by the low temperature rapid prototyping (LT-RP) 3D printing technology.

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Mechanics-driven nuclear localization of YAP can be reversed by N-cadherin ligation in mesenchymal stem cells.

Nature communications

Zhang C,Zhu H,Ren X,Gao B,Cheng B,Liu S,Sha B,Li Z,Zhang Z,Lv Y,Wang H,Guo H,Lu TJ,Xu F,Genin GM,Lin M

Published figure using Osteocalcin polyclonal antibody (Product # PA5-96529) in Immunocytochemistry

Thu Oct 28 00:00:00 EDT 2021

Mechanics-driven nuclear localization of YAP can be reversed by N-cadherin ligation in mesenchymal stem cells.

Nature communications

Zhang C,Zhu H,Ren X,Gao B,Cheng B,Liu S,Sha B,Li Z,Zhang Z,Lv Y,Wang H,Guo H,Lu TJ,Xu F,Genin GM,Lin M

Published figure using Osteocalcin polyclonal antibody (Product # PA5-96529) in Immunocytochemistry

Thu Oct 28 00:00:00 EDT 2021

生物信息学

蛋白别名: BGP; bone gamma carboxyglutamate protein 1; bone gamma-carboxyglutamate (gla) protein (osteocalcin); bone gamma-carboxyglutamate protein 2; bone gamma-carboxyglutamic acid (Gla) protein (osteocalcin); Bone Gla protein; bone Gla-protein; Gamma-carboxyglutamic acid-containing protein; OG1; Osteocalcin; PMF1; RP11-54H19.5

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基因别名: BGLAP; Bglap1; Bglap2; BGP; Bgpr; Bgpra; mOC-A; OC; OCN; OG1

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UniProt ID: (Human) P02818, (Mouse) P86546, (Rat) P04640

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Entrez Gene ID: (Human) 632, (Mouse) 12096, (Rat) 25295

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功能

structural molecule activity calcium ion binding structural constituent of bone hydroxyapatite binding metal ion binding

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