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Invitrogen
P-Glycoprotein Recombinant Rabbit Monoclonal Antibody (23GB1330)
高级验证
This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated.
图: 1 / 3
P-Glycoprotein Antibody (MA5-53174) in ICC/IF
Immunocytochemistry analysis of P-Glycoprotein (ABCB1) in HepG2 cells. Nuclei were stained blue with DAPI; P-Glycoprotein (ABCB1) recombinant monoclonal antibody (Product # MA5-53174) with a dilution of 1:1,000 was stained magenta with Alexa Fluor 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Low. Scale bar: 20 μm.
产品信息
MA5-53174
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
23GB1330
抗原
A synthesized peptide derived from human P Glycoprotein (350-750AA).
偶联物
形式
Liquid
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
靶标信息
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1); ATP-binding cassette sub-family B member 1; ATP-binding cassette sub-family B member 1A; ATP-binding cassette sub-family B member 1B; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1); ATP-binding cassette, sub-family B (MDR/TAP), member 1A; ATP-binding cassette, sub-family B (MDR/TAP), member 1B; ATP-binding cassette, sub-family B (MDR/TAP), member 4; ATP-binding cassette, subfamily B (MDR/TAP), member 1A; ATP-binding cassette, subfamily B, member 1A; ATP-binding cassette, subfamily B, member 1B; ATP-dependent translocase ABCB1; CD243; colchicin sensitivity; doxorubicin resistance; ecotropic viral integration site 32; MDR1A; multi-drug resistance 3; Multidrug resistance protein 1; Multidrug resistance protein 1A; Multidrug resistance protein 1B; Multidrug resistance protein 3; multiple drug resistant 1a; P glycoprotein 1; P glycoprotein 3; P-glycoprotein 1; P-glycoprotein 3; P-glycoprotein/multidrug resistance 1; Phospholipid transporter ABCB1
基因别名: ABC20; ABCB1; Abcb1a; Abcb1b; Abcb4; CD243; CLCS; Evi32; GP170; mdr; mdr-3; MDR1; Mdr1a; Mdr1b; Mdr3; P-GP; Pgp; Pgy-1; Pgy-3; PGY1; Pgy1-1; Pgy3
UniProt ID: (Human) P08183, (Mouse) P21447, (Mouse) P06795
Entrez Gene ID: (Human) 5243, (Mouse) 18671, (Rat) 170913, (Mouse) 18669, (Rat) 24646
transporter activity
protein binding
ATP binding
xenobiotic-transporting ATPase activity
ATPase activity, coupled to transmembrane movement of substances
nucleotide binding
hydrolase activity
ATPase activity
ATPase activity, coupled
drug transmembrane transporter activity
ATP-binding cassette (ABC) transporter
G2/M transition of mitotic cell cycle
antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent
positive regulation of antigen processing and presentation of peptide antigen via MHC class I
transport
drug transmembrane transport
response to drug
xenobiotic transport
transmembrane transport
stem cell proliferation
hormone transport
drug transport
daunorubicin transport
drug export
negative regulation of cell death
establishment of blood-brain barrier
positive regulation of response to drug
response to hypoxia
placenta development
lactation
circadian rhythm
metabolic process
response to organic cyclic compound
response to nutrient levels
response to vitamin D
cellular response to mycotoxin
response to cadmium ion
cellular response to antibiotic
cellular response to alkaloid
cellular response to estradiol stimulus
cellular response to organic cyclic compound
cellular hyperosmotic salinity response
response to dexamethasone
cellular response to dexamethasone stimulus
response to thyroxine
response to L-glutamate
establishment of endothelial blood-brain barrier
response to ionizing radiation
response to arsenic-containing substance
response to steroid hormone
cellular response to tumor necrosis factor
