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P-cadherin Antibody (MA3-24000-A555) in ICC/IF
Immunofluorescent analysis of p-Cadherin (orange) in A431 cells. The cells were permeabilized with 0.1% Triton X-100 in TBS for 15 minutes, and blocked with 3% Blocker BSA in PBS (Product # 37525) for 30 minutes at room temperature. Cells were stained with a p-Cadherin mouse monoclonal antibody, AlexaFluor 555 conjugate (Product # MA3-24000-A555), at a concentration of 10 µg/mL in blocking buffer for at lea... View More
产品信息
MA3-24000-A555
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
12H6
抗原
Human P-Cadherin fusion protein
偶联物
激发/发射光谱
553/568 nm
查看光谱
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
4° C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2662682
靶标信息
P-cadherin, also known as Cadherin-3, is a Type 1 cadherin protein that belongs to the cadherin superfamily. Type 1 cadherins are single-pass transmembrane proteins that have 5 extracellular cadherin repeats and an intracellular domain that binds p120-catenin and beta-catenin. Cadherins are calcium-dependent cell-cell adhesion glycoproteins responsible for a range of processes including development, wound healing, cell-cell signaling, cell growth and differentiation. P-cadherin is expressed in human fetal structures, and in adult tissues such as the basal layer of the epidermis, breast, prostate, ovary, cervix, hair follicle, and corneal endothelium. P-cadherin expression has also been reported on embryonic stem cells, and stem cells of the normal mammary gland, and hair follicle. Overexpression of P-cadherin has been associated with poor prognosis in breast, prostate, ovary, colon, and stomach carcinomas. Mutations in CDH3 are associated with congential hypotrichosis with juvenile macular dystrophy.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CADH3; cadherin 3, type 1, P-cadherin (placental); Cadherin-3; calcium-dependent adhesion protein, placental; P-cadherin; Placental cadherin; Placental-cadherin
基因别名: CDH3; CDHP; HJMD; PCAD
UniProt ID: (Human) P22223
Entrez Gene ID: (Human) 1001
retina homeostasis
cell adhesion
homophilic cell adhesion via plasma membrane adhesion molecules
visual perception
positive regulation of gene expression
positive regulation of keratinocyte proliferation
single organismal cell-cell adhesion
hair cycle process
keratinization
positive regulation of monophenol monooxygenase activity
negative regulation of transforming growth factor beta2 production
adherens junction organization
wound healing
response to drug
positive regulation of insulin-like growth factor receptor signaling pathway
positive regulation of melanin biosynthetic process
negative regulation of catagen
canonical Wnt signaling pathway
regulation of hair cycle by canonical Wnt signaling pathway
positive regulation of melanosome transport
