NeoBiotechnologies

P-glycoprotein/p170/MDR1/CD243 Recombinant Rabbit Monoclonal Antibody (MDR1/8986R)

P-glycoprotein/p170/MDR1/CD243 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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P-glycoprotein/p170/MDR1/CD243 Antibody (5243-RBM5-P1) in IHC (P)

Formalin-fixed, paraffin-embedded human adrenal gland stained with MDR1 Recombinant Rabbit Monoclonal Antibody (MDR1/8986R). HIER: Tris/EDTA, pH9.0, 45 min. 2°C: HRP-polymer, 30 min. DAB, 5 min.

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产品信息

5243-RBM5-P1

应用

建议稀释比

已发表文章

免疫组化（石蜡） (IHC (P))

1-2 µg/mL

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG, kappa

Expression System

HEK293 cells

分类

Recombinant Monoclonal

类型

Antibody

克隆号

MDR1/8986R

抗原

Recombinant fragment (around aa500-700) of human ABCB1 protein.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

200 µg/mL

纯化类型

Protein A/G

保存液

PBS with 0.05% BSA

内含物

0.05% sodium azide

保存条件

4° C

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Positive Control:hPBL or Jurkat whole cell lysate. Human adrenal gland.

Cellular Location: Membrane.

靶标信息

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: ATP-binding cassette sub-family B member 1; ATP-binding cassette, sub-family B (MDR/TAP), member 1; ATP-dependent translocase ABCB1; CD243; colchicin sensitivity; doxorubicin resistance; Multidrug resistance protein 1; P-glycoprotein 1; Phospholipid transporter ABCB1

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基因别名: ABC20; ABCB1; CD243; CLCS; GP170; MDR1; P-GP; PGY1

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UniProt ID: (Human) P08183

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Entrez Gene ID: (Human) 5243

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功能

transporter activity protein binding ATP binding xenobiotic-transporting ATPase activity ATPase activity, coupled to transmembrane movement of substances ATP-binding cassette (ABC) transporter

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