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产品信息
PA5-93144
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 55-338 of human P2RX4 (NP_0025512)
偶联物
Unconjugated
形式
Liquid
浓度
1.2 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2806640
产品详细信息
Immunogen sequence: QETDSVVSSV TTKVKGVAVT NTSKLGFRIW DVADYVIPAQ EENSLFVMTN VILTMNQTQG LCPEIPDATT VCKSDASCTA GSAGTHSNGV STGRCVAFNG SVKTCEVAAW CPVEDDTHVP QPAFLKAAEN FTLLVKNNIW YPKFNFSKRN ILPNITTTYL KSCIYDAKTD PFCPIFRLGK IVENAGHSFQ DMAVEGGIMG IQVNWDCNLD RAASLCLPRY SFRRLDTRDV EHNVSPGYNF RFAKYYRDLA GNEQRTLIKA YGIRFDIIVF GKAGKFDIIP TMIN; Positive Samples: 22Rv1, Mouse kidney, Mouse lung; Cellular Location: Membrane, Multi-pass membrane protein
靶标信息
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants have been identified for this gene although their full-length natures have not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP receptor; ATP-gated cation channel protein; ionotropic purinergic receptor; P2X purinoceptor 4; P2X receptor, subunit 4; P2X4; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 4; purinergic receptor P2X, ligand-gated ion channel, 4; purinergic receptor P2X4; purinergic receptor P2x4 subunit variant e; purinoceptor P2X4
基因别名: AI504491; AW555605; D5Ertd444e; P2RX4; P2X4; P2X4R
UniProt ID: (Human) Q99571
Entrez Gene ID: (Human) 5025, (Mouse) 18438
tissue homeostasis
regulation of sodium ion transport
transport
signal transduction
blood coagulation
regulation of blood pressure
positive regulation of calcium ion transport into cytosol
negative regulation of cardiac muscle hypertrophy
neuronal action potential
sensory perception of pain
positive regulation of prostaglandin secretion
response to ATP
ion transmembrane transport
response to fluid shear stress
purinergic nucleotide receptor signaling pathway
endothelial cell activation
positive regulation of nitric oxide biosynthetic process
positive regulation of calcium-mediated signaling
protein homooligomerization
membrane depolarization
positive regulation of calcium ion transport
regulation of cardiac muscle contraction
relaxation of cardiac muscle
cellular response to ATP
apoptotic signaling pathway
cation transmembrane transport
nitric oxide biosynthetic process
ion transport
calcium ion transport
vasodilation
excitatory postsynaptic potential
