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P2X4 Receptor Antibody (APR-002-200UL) in IHC
Expression of P2RX4 in rat brain - Immunohistochemical staining of rat brain red nucleus using Anti-P2X4 Receptor Antibody (#APR-002). A. P2RX4 (green) appears in fibers surrounding cell shapes (arrows). B. Calbindin 28K (red) appears in large neurons. C. Merge of P2RX4 and Calbindin 28K suggests variable density of P2RX4 expressing fibers on red nucleus neurons. DAPI is used as the counterstain (blue).
产品信息
APR-002-200UL
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
(C)KKYKYVEDYEQGLSGEMNQ, corresponding to amino acid residues 370-388 of rat P2X4 receptor, Intracellular, C-terminus
偶联物
形式
Lyophilized
浓度
0.8 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 1% BSA
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Reconstitution: 25 µL, 50 µL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
靶标信息
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants have been identified for this gene although their full-length natures have not been determined.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP receptor; ATP-gated cation channel protein; ionotropic purinergic receptor; P2X purinoceptor 4; P2X receptor, subunit 4; P2X4; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 4; purinergic receptor P2X, ligand-gated ion channel, 4; purinergic receptor P2X4; purinergic receptor P2x4 subunit variant e; purinoceptor P2X4
基因别名: AI504491; AW555605; D5Ertd444e; P2RX4; P2X4; P2X4R
UniProt ID: (Human) Q99571, (Rat) P51577
Entrez Gene ID: (Human) 5025, (Mouse) 18438, (Rat) 29659
tissue homeostasis
regulation of sodium ion transport
transport
signal transduction
blood coagulation
regulation of blood pressure
positive regulation of calcium ion transport into cytosol
negative regulation of cardiac muscle hypertrophy
neuronal action potential
sensory perception of pain
positive regulation of prostaglandin secretion
response to ATP
ion transmembrane transport
response to fluid shear stress
purinergic nucleotide receptor signaling pathway
endothelial cell activation
positive regulation of nitric oxide biosynthetic process
positive regulation of calcium-mediated signaling
protein homooligomerization
membrane depolarization
positive regulation of calcium ion transport
regulation of cardiac muscle contraction
relaxation of cardiac muscle
cellular response to ATP
apoptotic signaling pathway
cation transmembrane transport
nitric oxide biosynthetic process
ion transport
calcium ion transport
vasodilation
excitatory postsynaptic potential
