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P2X6 Antibody (PA5-116436) in IHC (P)
Immunohistochemical analysis of P2X6 in a paraffin-embedded mouse skeletal muscle tissue using a P2X6 polyclonal antibody (Product #PA5-116436). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (1:50) f... View More
产品信息
PA5-116436
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide within rat P2rx6 aa 340-389
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol, 0.2% BSA
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2901068
产品详细信息
Positive controls: Jurkat cell lysate, K562 cell lysate, rat skeletal muscle tissue, rat brain tissue, mouse skeletal muscle tissue, mouse heart tissue, SH-SY5Y.
靶标信息
P2rx6 encodes receptors that are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each P2rx6 receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains. The protein encoded by the P2rx6 gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. The P2rx6 gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants of P2rx6.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATP receptor; P2X purinoceptor 6; P2X6; P2X6 receptor; P2XM; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 6; purinergic receptor P2X, ligand-gated ion channel, 6; Purinergic receptor P2X-like 1; purinergic receptor P2X-like 1 orphan receptor; purinergic receptor P2X-like 1, orphan receptor; purinergic receptor P2X6; purinoceptor P2X6; purinoreceptor P2X6; skeletal muscle-expressed P2X
基因别名: P2RX6; P2RXL1; P2X6; P2XM; Rnap2x6
UniProt ID: (Human) F6V3D7, (Rat) P51579, (Mouse) O54803
Entrez Gene ID: (Human) 9127, (Rat) 25041, (Mouse) 18440
