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产品信息
H00005048-M01
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
2C12
抗原
PAFAH1B1 (NP_000421, 1 a.a. approximately 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: MVLSQRQRDE LNRAIADYLR SNGYEEAYSV FKKEAELDVN EELDKKYAGL LEKKWTSVIR LQKKVMELES KLNEAKEEFT SGGPLGQKRD PKEWIPRPPE KYALSGHRSP
靶标信息
VAMP7 is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family, localizing to late endosomes and lysosomes. VAMP7 is thought to mediate the fusion of endosomes to their target lysosomes as well as other exocytosis events during phagocytosis and neuritogenesis. VAMP7 interacts with the VPS9 ankyrin repeat protein VARP, a protein that localizes to early endosomes and thought to regulate endosome dynamics. Together with CD82, VAMP7 can modulate the signaling of EGFR by regulating its endocytosis from the plasma membrane.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: LIS-1; lissencephaly 1 protein; Lissencephaly-1 protein; MGC25297; PAF acetylhydrolase 45 kDa subunit; PAF-AH 45 kDa subunit; PAF-AH alpha; PAFAH alpha; PAFAH1B1; platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa); Platelet-activating factor acetylhydrolase IB subunit beta; platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit (45kD); platelet-activating factor acetylhydrolase, isoform Ib, subunit 1 (45kDa); RP23-194P5.2
基因别名: LIS1; LIS2; MDCR; MDS; NudF; PAFAH; PAFAH1B1; PAFAHA
UniProt ID: (Human) P43034
Entrez Gene ID: (Human) 5048
G2/M transition of mitotic cell cycle
establishment of mitotic spindle orientation
microtubule cytoskeleton organization
ameboidal-type cell migration
acrosome assembly
neuron migration
positive regulation of cytokine-mediated signaling pathway
microtubule-based process
sister chromatid cohesion
mitotic nuclear division
nuclear migration
chemical synaptic transmission
germ cell development
neuroblast proliferation
learning or memory
retrograde axonal transport
adult locomotory behavior
protein secretion
negative regulation of neuron projection development
lipid catabolic process
stem cell division
transmission of nerve impulse
corpus callosum morphogenesis
hippocampus development
layer formation in cerebral cortex
cerebral cortex neuron differentiation
cerebral cortex development
actin cytoskeleton organization
microtubule organizing center organization
osteoclast development
positive regulation of embryonic development
establishment of planar polarity of embryonic epithelium
regulation of GTPase activity
cortical microtubule organization
positive regulation of axon extension
positive regulation of mitotic cell cycle
negative regulation of JNK cascade
platelet activating factor metabolic process
vesicle transport along microtubule
brain morphogenesis
neuromuscular process controlling balance
nuclear envelope disassembly
establishment of centrosome localization
auditory receptor cell development
positive regulation of dendritic spine morphogenesis
regulation of microtubule cytoskeleton organization
cochlea development
microtubule cytoskeleton organization involved in establishment of planar polarity
regulation of microtubule motor activity
