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This target displays homology in the following species: Cow: 85%; Guinea Pig: 85%; Horse: 92%; Human: 100%; Mouse: 86%; Pig: 92%; Rabbit: 85%; Rat: 86%
Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion (PubMed:12477380). Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs (PubMed:12477380). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: peroxisomal N(1)-acetyl-spermine/spermidine oxidase; putative GTP-binding protein
Entrez Gene ID: (Rat) 293589