Fabgennix

PAR1 Polyclonal Antibody, Biotin

查看其他18个PAR1抗体

产品信息

PAR1-BIOTIN

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

-

酶联免疫吸附实验 (ELISA)

1:10,000

-

免疫沉淀 (IP)

1:50-1:250

-

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide taken within amino acid region 390-440 on mouse PAR1 protein.

偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

0.5-1.5 mg/mL

纯化类型

Affinity chromatography

保存液

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

Thrombin is a serine protease that is involved in platelet aggregation and blood coagulation. It is cleaved from its precursor, prothrombin, and converts fibrinogen to fibrin in the final step of the clotting cascade. Thrombin mediates its regulatory effects by activating cell surface G-protein coupled receptors which include PAR-1, PAR-2 and PAR3.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: C HTR; coagulation factor II (thrombin) receptor; Coagulation factor II receptor; PAR-1; protease activated receptor 1; protease-activated receptor 1; Proteinase-activated receptor 1; Thrombin receptor

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基因别名: AI482343; CF2R; F2R; HTR; PAR-1; PAR1; ThrR; TR; TRGPC

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UniProt ID: (Human) P25116, (Mouse) P30558

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Entrez Gene ID: (Human) 2149, (Mouse) 14062, (Rat) 25439

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G-protein alpha-subunit binding G-protein coupled receptor activity receptor binding protein binding thrombin receptor activity G-protein beta-subunit binding signal transducer activity heterotrimeric G-protein binding G-protein coupled receptor

参与通路

activation of MAPKK activity connective tissue replacement involved in inflammatory response wound healing negative regulation of glomerular filtration activation of cysteine-type endopeptidase activity involved in apoptotic process inflammatory response G-protein coupled receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration protein kinase C-activating G-protein coupled receptor signaling pathway tyrosine phosphorylation of STAT protein STAT protein import into nucleus establishment of synaptic specificity at neuromuscular junction blood coagulation positive regulation of cell proliferation negative regulation of cell proliferation response to wounding anatomical structure morphogenesis positive regulation of phosphatidylinositol 3-kinase signaling platelet activation regulation of blood coagulation positive regulation of blood coagulation positive regulation of cell migration response to lipopolysaccharide regulation of interleukin-1 beta production positive regulation of collagen biosynthetic process positive regulation of Rho protein signal transduction positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of cysteine-type endopeptidase activity involved in apoptotic process positive regulation of MAPK cascade negative regulation of neuron apoptotic process positive regulation of transcription, DNA-templated positive regulation of vasoconstriction positive regulation of smooth muscle contraction positive regulation of JAK-STAT cascade homeostasis of number of cells within a tissue release of sequestered calcium ion into cytosol positive regulation of release of sequestered calcium ion into cytosol positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway positive regulation of calcium ion transport regulation of sensory perception of pain platelet dense granule organization positive regulation of ERK1 and ERK2 cascade thrombin receptor signaling pathway negative regulation of renin secretion into blood stream positive regulation of interleukin-8 secretion positive regulation of interleukin-6 secretion signal transduction hemostasis obsolete death