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NeoBiotechnologies
PBX1/PRL (Transcription Factor) Monoclonal Antibody (PCRP-PBX1-3C8)
产品信息
5087-MSM2-P1ABX
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
PCRP-PBX1-3C8
抗原
Recombinant full-length human PBX1 protein
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A/G
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
靶标信息
This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis, and required for skeletal patterning and programming. A chromosomal translocation, t(1; 19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp686B09108; Homeobox protein PBX1; Homeobox protein PRL; MGC126627; OTTHUMP00000032205; pre-B-cell leukemia homeobox 1; Pre-B-cell leukemia transcription factor 1
基因别名: PBX1; PRL
UniProt ID: (Human) P40424
Entrez Gene ID: (Human) 5087
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein heterodimerization activity
homeodomain transcription factor
branching involved in ureteric bud morphogenesis
transcription from RNA polymerase II promoter
steroid biosynthetic process
sex differentiation
positive regulation of cell proliferation
anterior/posterior pattern specification
proximal/distal pattern formation
positive regulation of G2/M transition of mitotic cell cycle
regulation of ossification
adrenal gland development
embryonic limb morphogenesis
somatic stem cell population maintenance
embryonic hemopoiesis
negative regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
spleen development
thymus development
embryonic skeletal system development
