Search Thermo Fisher Scientific
Recommended positive controls: A431.
Predicted reactivity: Mouse (98%), Chicken (88%), Bovine (97%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Protocadherin 1, also known as PCDH1 and cadherin-like protein 1, is a transmembrane protein involved in cell-cell adhesion. Protocadherin 1 belongs to a group of cadherin-like proteins termed delta1-protocadherins, which consists of protocadherin-1, -7, -9, and -11(X/Y). The delta1-protocadherins have seven extracellular cadherin-repeats, a transmembrane domain, and a cytoplasmic domain, and can be expressed in two isoforms, short or long. Expression of protocadherin 1 is regulated both temporally and spatially, and plays a role both in early development and mature tissues. In mice, it is expressed in a number of tissues and organs, including the brain, spinal cord, peripheral ganglia, inner ear, hair follicles, kidney, reproductive organs, prostate, and the seminal gland. Notably, protocadherin 1 is a susceptibility gene for Bronchial Hyperresponsiveness in humans. Expression of protocadherin 1 has also been identified on human pluripotent stem cells.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: cadherin-like 1; Cadherin-like protein 1; PC42; protocadherin 42; Protocadherin-1; Protocadherin-42
基因别名: PC42; PCDH1; PCDH42
UniProt ID: (Human) Q08174
Entrez Gene ID: (Human) 5097
分子生物学功能:
cadherin