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PDE10A Antibody (MA5-55515) in WB
Western Blot analysis of various lysates using PDE10A Recombinant Monoclonal Antibody (Product # MA5-55515) at 1:1,000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) at 1:10,000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
产品信息
MA5-55515
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
8J7E5
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 439-779 of human PDE10A.
偶联物
形式
Liquid
浓度
0.49 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.05% ProClin 300
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Dry ice (international)
产品详细信息
Immunogen Sequence: SICTSEEWQG LMQFTLPVRL CKEIELFHFD IGPFENMWPG IFVYMVHRSC GTSCFELEKL CRFIMSVKKN YRRVPYHNWK HAVTVAHCMY AILQNNHTLF TDLERKGLLI ACLCHDLDHR GFSNSYLQKF DHPLAALYST STMEQHHFSQ TVSILQLEGH NIFSTLSSSE YEQVLEIIRK AIIATDLALY FGNRKQLEEM YQTGSLNLNN QSHRDRVIGL MMTACDLCSV TKLWPVTKLT ANDIYAEFWA EGDEMKKLGI QPIPMMDRDK KDEVPQGQLG FYNAVAIPCY TTLTQILPPT EPLLKACRDN LSQWEKVIRG EETATWISSP SVAQKAAASE D
靶标信息
Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; dual-substrate cAMP and cGMP, cyclic nucleotide phosphodiesterase; FLJ11894; FLJ25677; PDE10A2 brain-specific isoform; testis-specific phosphodiesterase PDE10A2
基因别名: Pde10a; Pde10a3
UniProt ID: (Mouse) Q8CA95, (Rat) Q9QYJ6
Entrez Gene ID: (Mouse) 23984, (Rat) 63885
nucleotide binding
catalytic activity
cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
phosphoric diester hydrolase activity
drug binding
hydrolase activity
cAMP binding
cGMP binding
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
phosphodiesterase
