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Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Bat, Hamster, Elephant, Horse, Rabbit, Pig, Opossum, Turkey, Chicken, Pufferfish, Zebrafish (100%); Platypus, Xenopus, Stickleback (94%); Dog (88%).
For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: cAMP and cGMP cyclic nucleotide phosphodiesterase 11A; cAMP and cGMP phosphodiesterase 11A; Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A; FLJ23693; MGC133355; MGC133356; phosphodiesterase 11A; Tetratricopeptide repeat protein 30A1
基因别名: 6330414F14Rik; A630086N24Rik; Gm350; I79_007367; PDE11A; PDE11A1; PPNAD2; si:ch211-222f23.5
UniProt ID: (Human) Q9HCR9, (Mouse) P0C1Q2, (Rat) Q8VID6
Entrez Gene ID: (Chinese hamster) 100756511, (Bovine) 524446, (Rabbit) 100341520, (Pig) 100738835, (Chicken) 424133, (Human) 50940, (Horse) 100053692, (Mouse) 241489, (Rat) 140928, (Zebrafish) 561338
分子生物学功能:
phosphodiesterase