Fabgennix

PDE12 Polyclonal Antibody, Biotin

产品信息

PD12-BIOTIN

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:1,000

免疫组化 (IHC)

1:50-1:250

酶联免疫吸附实验 (ELISA)

1:10,000

免疫沉淀 (IP)

1:50-1:250

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide taken within amino acid region 420-470 on human PDE12A protein.

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偶联物

Biotin Biotin Biotin

形式

Liquid

浓度

0.5-1.5 mg/mL

纯化类型

Affinity chromatography

保存液

proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

PDE12 is an enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. It also cleaves 3',5'-phosphodiester bond of oligoadenylates and plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

仅用于科研。不用于诊断过程。未经明确授权不得转售。