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PDE1B Antibody (PA5-53817) in WB
Western blot analysis of PDE1B in control (vector only transfected HEK293T lysate) and PDE1B over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (~3.1 kDa) in mammalian HEK293T cells). Samples were probed using a PDE1B Polyclonal Antibody (Product # PA5-53817).
产品信息
PA5-53817
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2645324
产品详细信息
Immunogen sequence: TFSVLTDVAE KSVQPLADED SKSKNQPSFQ WRQPSLDVEV GDPNPDVVSF RSTWVKRIQE NKQKWKERAA SGITNQMSID ELSPCEEEAP PSPAEDEHNQ NGN
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.
靶标信息
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 63 a Cam PDE; 63 a Cam-PDE; 63 kDa Cam-PDE; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; calmodulin-stimulated phosphodiesterase PDE1B1; Cam PDE 1B; Cam PDE1B; Cam-PDE 1B; Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; epididymis secretory sperm binding protein Li 79p; PDE 1B; PDES 1B; Phosphodiesterase; phosphodiesterase 1B, calmodulin-dependent; presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B
基因别名: HEL-S-79p; PDE1B; PDE1B1; PDES1B
UniProt ID: (Human) Q01064
Entrez Gene ID: (Human) 5153
3',5'-cyclic-AMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
protein binding
calmodulin binding
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
phosphodiesterase
regulation of neurotransmitter levels
response to amphetamine
cAMP catabolic process
apoptotic process
signal transduction
locomotory behavior
visual learning
monocyte differentiation
cellular response to macrophage colony-stimulating factor stimulus
regulation of dopamine metabolic process
serotonin metabolic process
cGMP catabolic process
cellular response to granulocyte macrophage colony-stimulating factor stimulus
