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产品信息
MA5-31832
产品规格
种属反应
Human,
Mouse,
Non-human primate
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
10B10B12
抗原
Purified recombinant fragment of human PDE1B (AA: 370-536) expressed in E. coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2787455
产品详细信息
MA5-31832 has been tested in indirect ELISA.
靶标信息
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 63 a Cam PDE; 63 a Cam-PDE; 63 kDa Cam-PDE; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; calmodulin-stimulated phosphodiesterase PDE1B1; Cam PDE 1B; Cam PDE1B; Cam-PDE 1B; Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B; epididymis secretory sperm binding protein Li 79p; PDE 1B; PDES 1B; Phosphodiesterase; phosphodiesterase 1B, Ca2+-calmodulin dependent, 63 kDa; phosphodiesterase 1B, calmodulin-dependent; phosphodiesterase 1B1, Ca2+-calmodulin dependent, 63 kDa; presumed 63kDa form of the type 1 cyclic nucleotide phosphodiesterase family known as PDE1B
基因别名: HEL-S-79p; PDE1B; PDE1B1; PDES1B
UniProt ID: (Human) Q01064, (Mouse) Q01065
Entrez Gene ID: (Human) 5153, (Mouse) 18574
3',5'-cyclic-AMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
protein binding
calmodulin binding
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
phosphoric diester hydrolase activity
hydrolase activity
phosphodiesterase
regulation of neurotransmitter levels
response to amphetamine
cAMP catabolic process
apoptotic process
signal transduction
locomotory behavior
visual learning
monocyte differentiation
cellular response to macrophage colony-stimulating factor stimulus
regulation of dopamine metabolic process
serotonin metabolic process
cGMP catabolic process
cellular response to granulocyte macrophage colony-stimulating factor stimulus
