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产品信息
PD3B-131-FITC
产品规格
种属反应
Chicken,
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide taken within amino acid region 260-310 on human PDE3B protein. Selective only for PDE3B variant.
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: CGI PDE; CGI-PDE B; CGIP1; CGIPDE1; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B; Cyclic GMP-inhibited phosphodiesterase B; cyclic nucleotide phosphodiesterase; phosphodiesterase 3B cGMP inhibited; phosphodiesterase 3B, cGMP-inhibited; RcGIPl
基因别名: 9830102A01Rik; AI847709; cGIPDE1; HcGIP1; PDE3B
UniProt ID: (Human) Q6SEI4, (Mouse) Q61409, (Rat) Q63085
Entrez Gene ID: (Chicken) 423064, (Human) 5140, (Mouse) 18576, (Rat) 29516
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
protein binding
protein kinase B binding
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
phosphoric diester hydrolase activity
drug binding
hydrolase activity
cAMP binding
phosphoprotein binding
phosphodiesterase
angiogenesis
cAMP catabolic process
negative regulation of cell adhesion
signal transduction
negative regulation of angiogenesis
cellular response to insulin stimulus
negative regulation of cell adhesion mediated by integrin
negative regulation of cAMP-mediated signaling
negative regulation of lipid catabolic process
endocrine pancreas development
glucose homeostasis
negative regulation of insulin secretion
regulation of insulin secretion
diterpenoid metabolic process
