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产品信息
PD4-101AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Chicken,
Human,
Mouse,
Non-human primate,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide common to most PDE4 subtypes: PDE4A, PDE4D, PDE4B
偶联物
Unconjugated
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 on cyclic adenosine monophosphate. It is a member of the larger family of PDE inhibitors. The PDE4 family of enzymes are the most prevalent PDE in immune cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3',5'-cyclic-AMP phosphodiesterase 4A; 3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4A; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4A; cAMP-specific phosphodiesterase PDE4D; cAMP-specific phosphodiesterase PDE4D6; cAMP-specific phosphodiesterase splice variant PDE4D8; cyclic AMP specific phosphodiesterase PDE4A5A; cyclic AMP specific phosphodiesterase PDE4D5A; DPDE2; DPDE3; dunce; PDE43; PDE46; phosphodiesterase 4A, cAMP specific; phosphodiesterase 4A, cAMP-specific (dunce; phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila); Phosphodiesterase 4D cAMP-specific (dunce; phosphodiesterase 4D, cAMP specific; phosphodiesterase 4D, cAMP-specific; Phosphodiesterase 4D, cAMP-specific (dunce; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); phosphodiesterase E2 dunce homolog, Drosophila; phosphodiesterase isozyme 4; testicular tissue protein Li 136
基因别名: 9630011N22Rik; ACRDYS2; D9Ertd60e; DPDE2; DPDE3; HSPDE4D; PDE4; PDE43; PDE46; PDE4A; PDE4D; PDE4DN2; PHOSA; STRK1
UniProt ID: (Human) P27815, (Human) Q08499, (Mouse) O89084, (Rat) P54748, (Rat) P14270, (Mouse) Q01063
Entrez Gene ID: (Human) 5141, (Chicken) 769469, (Human) 5144, (Mouse) 18577, (Rat) 25638, (Rat) 24627, (Mouse) 238871
3',5'-cyclic-AMP phosphodiesterase activity
protein binding
cAMP binding
metal ion binding
3',5'-cyclic-nucleotide phosphodiesterase activity
drug binding
enzyme binding
beta-2 adrenergic receptor binding
ion channel binding
ATPase binding
scaffold protein binding
phosphoric diester hydrolase activity
hydrolase activity
cyclic-nucleotide phosphodiesterase activity
SH3 domain binding
protein domain specific binding
ubiquitin protein ligase binding
phosphodiesterase
cAMP catabolic process
signal transduction
sensory perception of smell
regulation of protein kinase A signaling
cellular response to drug
regulation of cAMP-mediated signaling
regulation of heart rate
smooth muscle contraction
aging
regulation of receptor activity
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
cAMP-mediated signaling
neutrophil chemotaxis
regulation of cAMP metabolic process
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-5 production
negative regulation of peptidyl-serine phosphorylation
multicellular organism growth
negative regulation of heart contraction
T cell receptor signaling pathway
regulation of ryanodine-sensitive calcium-release channel activity
establishment of endothelial barrier
cellular response to lipopolysaccharide
cellular response to epinephrine stimulus
adrenergic receptor signaling pathway
regulation of cardiac muscle cell contraction
adrenergic receptor signaling pathway involved in positive regulation of heart rate
regulation of cell communication by electrical coupling involved in cardiac conduction
negative regulation of relaxation of cardiac muscle
metabolic process
response to drug
memory
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of smooth muscle cell migration
lung development
cellular protein complex assembly
positive regulation of smooth muscle cell proliferation
leukocyte migration
cellular response to cAMP
