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产品信息
PA5-99682
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PDE4B(Accession Q07343), corresponding to amino acid residues G36-A86.
偶联物
Unconjugated
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2818615
产品详细信息
Antibody detects endogenous levels of total PDE4B/C/D.
靶标信息
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3',5'-cyclic-AMP phosphodiesterase 4B; 3',5'-cyclic-AMP phosphodiesterase 4C; 3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4B; cAMP-specific phosphodiesterase 4C; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D6; cyclic AMP specific phosphodiesterase PDE4D5A; DPDE1; DPDE3; DPDE4; dunce; dunce-like phosphodiesterase E4; PDE21; PDE32; PDE43; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila); phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila); phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); phosphodiesterase E1 dunce homolog; testicular tissue protein Li 136
基因别名: 9630011N22Rik; ACRDYS2; DPDE1; DPDE3; DPDE4; dunce; E130301F19Rik; HSPDE4D; PDE43; PDE4B; PDE4C; PDE4D; PDE4DN2; PDEIVB; R74983; STRK1
UniProt ID: (Human) Q07343, (Human) Q08493, (Human) Q08499, (Mouse) Q3UEI1, (Mouse) Q01063
Entrez Gene ID: (Human) 5142, (Human) 5143, (Human) 5144, (Mouse) 18578, (Mouse) 110385, (Mouse) 238871
3',5'-cyclic-AMP phosphodiesterase activity
cAMP binding
gamma-tubulin binding
ion channel binding
metal ion binding
drug binding
3',5'-cyclic-nucleotide phosphodiesterase activity
protein binding
enzyme binding
beta-2 adrenergic receptor binding
ATPase binding
scaffold protein binding
phosphoric diester hydrolase activity
hydrolase activity
phosphodiesterase
neutrophil homeostasis
cAMP catabolic process
neutrophil chemotaxis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
cellular response to drug
T cell receptor signaling pathway
leukocyte migration
cellular response to lipopolysaccharide
cellular response to epinephrine stimulus
regulation of cardiac muscle cell contraction
regulation of high voltage-gated calcium channel activity
negative regulation of relaxation of cardiac muscle
signal transduction
negative regulation of insulin secretion
regulation of heart rate
smooth muscle contraction
aging
regulation of receptor activity
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
cAMP-mediated signaling
regulation of cAMP metabolic process
positive regulation of interleukin-5 production
negative regulation of peptidyl-serine phosphorylation
multicellular organism growth
negative regulation of heart contraction
regulation of ryanodine-sensitive calcium-release channel activity
establishment of endothelial barrier
adrenergic receptor signaling pathway
adrenergic receptor signaling pathway involved in positive regulation of heart rate
regulation of cell communication by electrical coupling involved in cardiac conduction
