Target of Interest
Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Application
图: 1 / 1
PDE4D4 Antibody (PD4D4-441AP) in WB
WB of long-form PDE4D variants in mouse prefrontal cortical tissues using PD4D4-441AP. Courtesy of Wang, Z.-Z. et al. Phosphodiesterase-4D Knock-down in the Prefrontal Cortex Alleviates Chronic Unpredictable Stress-Induced Depressive-Like Behaviors and Memory Deficits in Mice. Sci. Rep. (2015).
产品信息
PD4D4-441AP
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to unique amino acid sequence on PDE4D4 variant gene.
偶联物
Unconjugated
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: 3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D; cAMP-specific phosphodiesterase splice variant PDE4D8; cyclic AMP specific phosphodiesterase PDE4D5A; DPDE3; dunce; PDE4D; Phosphodiesterase 4D cAMP-specific (dunce; phosphodiesterase 4D, cAMP specific; Phosphodiesterase 4D, cAMP-specific (dunce; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila)
基因别名: 9630011N22Rik; Dpde3; Pde4d
UniProt ID: (Rat) P14270, (Mouse) Q01063
Entrez Gene ID: (Rat) 24627, (Mouse) 238871
cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
protein binding
drug binding
SH3 domain binding
enzyme binding
protein domain specific binding
cAMP binding
ubiquitin protein ligase binding
beta-2 adrenergic receptor binding
ion channel binding
metal ion binding
ATPase binding
scaffold protein binding
phosphoric diester hydrolase activity
hydrolase activity
phosphodiesterase
regulation of heart rate
cAMP catabolic process
smooth muscle contraction
aging
memory
regulation of G-protein coupled receptor protein signaling pathway
regulation of receptor activity
regulation of protein kinase A signaling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
positive regulation of smooth muscle cell migration
lung development
neutrophil chemotaxis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-5 production
negative regulation of peptidyl-serine phosphorylation
multicellular organism growth
cellular protein complex assembly
negative regulation of heart contraction
positive regulation of smooth muscle cell proliferation
T cell receptor signaling pathway
leukocyte migration
regulation of ryanodine-sensitive calcium-release channel activity
establishment of endothelial barrier
cellular response to lipopolysaccharide
cellular response to cAMP
cellular response to epinephrine stimulus
adrenergic receptor signaling pathway
regulation of cardiac muscle cell contraction
adrenergic receptor signaling pathway involved in positive regulation of heart rate
negative regulation of relaxation of cardiac muscle
signal transduction
regulation of cell communication by electrical coupling involved in cardiac conduction
