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PDGF-B Antibody (PA5-81531) in WB
Western Blot using PDGF-B Polyclonal Antibody (Product # PA5-81531) at 1:500 dilution. Lane A: A375 Whole Cell Lysate. Lysates/proteins at 30 μg per lane. Secondary Goat Anti- RabbitIgG H&L (DyLight™ 800) at 1:10,000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 27 kDa. Observed band size: 24 kDa.
产品信息
PA5-81531
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to the C-terminus of the Human PDGF-B/PDGF-2
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2788735
产品详细信息
This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human PDGF-B.
靶标信息
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: becaplermin; PDGF subunit B; PDGF, B chain; PDGF-2; platelet-derived growth factor 2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog); Platelet-derived growth factor subunit B; platelet-derived growth factor, beta polypeptide (oncogene SIS); Proto-oncogene c-Sis
基因别名: c-sis; IBGC5; PDGF-2; PDGF2; PDGFB; SIS; SSV
UniProt ID: (Human) P01127
Entrez Gene ID: (Human) 5155
Ras guanyl-nucleotide exchange factor activity
platelet-derived growth factor receptor binding
protein binding
collagen binding
growth factor activity
superoxide-generating NADPH oxidase activator activity
chemoattractant activity
identical protein binding
protein homodimerization activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
protein heterodimerization activity
platelet-derived growth factor binding
growth factor
MAPK cascade
response to hypoxia
embryonic placenta development
positive regulation of endothelial cell proliferation
monocyte chemotaxis
platelet degranulation
positive regulation of glomerular filtration
DNA replication
protein phosphorylation
transforming growth factor beta receptor signaling pathway
heart development
positive regulation of cell proliferation
response to wounding
negative regulation of phosphatidylinositol biosynthetic process
negative regulation of platelet activation
positive regulation of gene expression
negative regulation of gene expression
regulation of phosphatidylinositol 3-kinase signaling
positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of smooth muscle cell migration
cell growth
peptidyl-serine phosphorylation
peptidyl-tyrosine phosphorylation
hemopoiesis
extracellular matrix organization
positive regulation of cell migration
positive regulation of protein autophosphorylation
negative regulation of protein binding
activation of protein kinase activity
activation of protein kinase B activity
response to estradiol
response to insulin
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
paracrine signaling
wound healing
response to drug
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
positive regulation of blood vessel endothelial cell migration
positive regulation of GTPase activity
positive regulation of phosphatidylinositol 3-kinase activity
response to estrogen
positive regulation of cyclin-dependent protein serine/threonine kinase activity
positive regulation of DNA replication
positive regulation of mitotic nuclear division
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
phosphatidylinositol phosphorylation
platelet-derived growth factor receptor signaling pathway
phosphatidylinositol-mediated signaling
positive regulation of fibroblast proliferation
positive regulation of smooth muscle cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
positive regulation of chemotaxis
positive regulation of cell division
cell chemotaxis
positive regulation of protein tyrosine kinase activity
positive regulation of ERK1 and ERK2 cascade
protein kinase C signaling
cellular response to growth factor stimulus
cellular response to mycophenolic acid
positive regulation of glomerular mesangial cell proliferation
metanephric glomerular mesangial cell development
reactive oxygen species metabolic process
positive regulation of calcium ion import
positive regulation of hyaluronan biosynthetic process
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of vascular smooth muscle cell proliferation
positive regulation of vascular associated smooth muscle cell migration
negative regulation of vascular smooth muscle cell differentiation
positive regulation of vascular smooth muscle cell dedifferentiation
positive regulation of reactive oxygen species metabolic process
positive regulation of DNA biosynthetic process
positive regulation of metanephric mesenchymal cell migration
