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产品信息
MA5-17281
产品规格
种属反应
Human,
Rat
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
GT533
抗原
Recombinant fragment contains a sequence corresponding to a region within amino acids 15 and 299 of PEX19
偶联物
形式
Liquid
浓度
1.17 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
no preservative
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2538747
产品详细信息
Recommended positive controls: Jurkat, Raji, K562, THP-1, NCI-H929, PC-12, Rat2.
Predicted reactivity: Mouse (91%), Rat (93%), Bovine (95%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
This gene is necessary for early peroxisomal biogenesis. It acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause Zellweger syndrome (ZWS).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 33 kDa housekeeping protein; housekeeping gene, 33kD; Peroxin-19; Peroxisomal biogenesis factor 19; Peroxisomal farnesylated protein; peroxisome biogenesis factor 19
基因别名: D1S2223E; HK33; OK/SW-cl.22; PBD12A; PEX19; PMP1; PMPI; PXF; PXMP1
UniProt ID: (Human) G3V3G9
Entrez Gene ID: (Human) 5824, (Rat) 289233
protein targeting to peroxisome
peroxisome organization
peroxisome fission
protein import into peroxisome membrane
protein stabilization
transmembrane transport
chaperone-mediated protein folding
chaperone-mediated protein transport
establishment of protein localization to peroxisome
negative regulation of lipid binding
biological_process
peroxisome membrane biogenesis
