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PEX5 Antibody (PA5-76823) in IHC (P)
Immunohistochemistry analysis of PEX5 in paraffin-embedded human liver damage. Samples were incubated with PEX5 polyclonal antibody (Product # PA5-76823) using a dilution of 1:100. Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
产品信息
PA5-76823
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant full length Human PEX5.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 50% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2720550
产品详细信息
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
靶标信息
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: peroxin 5; Peroxin-5; peroxisomal biogenesis factor 5; Peroxisomal C-terminal targeting signal import receptor; peroxisomal targeting signal 1 (SKL type) receptor; Peroxisomal targeting signal 1 receptor; peroxisomal targeting signal import receptor; peroxisomal targeting signal receptor 1; peroxisome biogenesis factor 5; Peroxisome receptor 1; PTS1 BP; PTS1 receptor; PTS1-BP; PXR1P
基因别名: AW212715; ESTM1; PBD2A; PBD2B; PEX5; Pex5_predicted; PTS1-BP; PTS1R; PXR1; RCDP5; X83306
UniProt ID: (Human) P50542, (Mouse) O09012, (Rat) Q2M2R8
Entrez Gene ID: (Human) 5830, (Mouse) 19305, (Rat) 312703
protein import into peroxisome matrix
protein import into peroxisome matrix, docking
protein import into peroxisome membrane
negative regulation of protein homotetramerization
very long-chain fatty acid metabolic process
neuron migration
protein targeting to peroxisome
fatty acid beta-oxidation
transport
mitochondrion organization
mitochondrial membrane organization
endoplasmic reticulum organization
peroxisome organization
isoprenoid biosynthetic process
protein transport
protein import into peroxisome matrix, translocation
cerebral cortex cell migration
cerebral cortex neuron differentiation
positive regulation of multicellular organism growth
cellular lipid metabolic process
cell development
neuromuscular process
protein tetramerization
biological_process
