Invitrogen

PF4 Monoclonal Antibody (KKO)

查看其他19个PF4抗体

产品信息

MA5-17641

应用

建议稀释比

已发表文章

免疫印迹 (WB)

Assay-dependent

-

酶联免疫吸附实验 (ELISA)

Assay-dependent

-

产品规格

种属反应

Human

宿主/亚型

Mouse / IgG2b, kappa

分类

Monoclonal

类型

Antibody

克隆号

KKO

抗原

Human Factor IV purified from the supernatant of thrombin activated platelets.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS

内含物

0.02% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2539031

产品详细信息

MA5-17641 targets Platelet Factor 4 in ELISA and WB applications and shows reactivity with Human samples.

The MA5-17641 immunogen is human Factor IV purified from the supernatant of thrombin activated platelets.

靶标信息

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair (Eisman et al., 1990).

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: C-X-C motif chemokine 4; chemokine (C-X-C motif) ligand 4; Iroplact; Oncostatin-A; PF-4; Platelet factor 4

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基因别名: CXCL4; PF-4; PF4; SCYB4

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UniProt ID: (Human) P02776

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Entrez Gene ID: (Human) 5196

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chemokine activity heparin binding CXCR3 chemokine receptor binding chemokine

参与通路

platelet degranulation positive regulation of leukocyte chemotaxis inflammatory response immune response G-protein coupled receptor signaling pathway positive regulation of gene expression positive regulation of macrophage derived foam cell differentiation negative regulation of angiogenesis cytokine-mediated signaling pathway platelet activation leukocyte chemotaxis positive regulation of cAMP metabolic process response to lipopolysaccharide positive regulation of tumor necrosis factor production regulation of cell proliferation positive regulation of cAMP-mediated signaling negative regulation of MHC class II biosynthetic process positive regulation of macrophage differentiation negative regulation of megakaryocyte differentiation negative regulation of cytolysis positive regulation of transcription from RNA polymerase II promoter chemokine-mediated signaling pathway negative regulation of extrinsic apoptotic signaling pathway in absence of ligand