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产品信息
PGCB-FITC
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase B protein.
偶联物
激发/发射光谱
498/517 nm
查看光谱
形式
Liquid
浓度
0.5-1.5 mg/mL
纯化类型
Affinity chromatography
保存液
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20° C, store in dark
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide, which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ANP-B; ANPR-B; ANPRB; atrial natriuretic peptide B-type receptor; Atrial natriuretic peptide receptor 2; atrial natriuretic peptide receptor B; Atrial natriuretic peptide receptor type B; GC-B; guanylate cyclase 2B; Guanylate cyclase B; guanylyl cyclase-B; natriuretic peptide receptor B type; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); natriuretic peptide receptor-B; Nppb receptor; NPR-B
基因别名: AMDM; ANPb; ANPRB; cn; ECDM; GC-B; GC-B2; GC-B3; GUC2B; GUCY2B; mNPR-B; NPR-B; NPR2; NPRB; NPRBi; pwe; SNSK
UniProt ID: (Human) P20594, (Rat) P16067, (Mouse) Q6VVW5
Entrez Gene ID: (Human) 4882, (Rat) 116564, (Mouse) 230103
adenylate cyclase activity
guanylate cyclase activity
protein kinase activity
ATP binding
GTP binding
natriuretic peptide receptor activity
peptide hormone binding
hormone binding
identical protein binding
nucleotide binding
transferase activity, transferring phosphorus-containing groups
lyase activity
phosphorus-oxygen lyase activity
guanylate cyclase
ossification
cGMP biosynthetic process
protein phosphorylation
receptor guanylyl cyclase signaling pathway
regulation of blood pressure
intracellular signal transduction
single organism reproductive process
negative regulation of meiotic cell cycle
bone development
cellular response to granulocyte macrophage colony-stimulating factor stimulus
negative regulation of oocyte maturation
regulation of cardiac conduction
signal transduction
cyclic nucleotide biosynthetic process
