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PGRP-1b Antibody (PA5-116290) in WB
Western Blot analysis of PGRP-1b using the PGRP-1b Polyclonal Antibody (Product # PA5-116290) at a 1:1000 dilution. HACAT whole cell lysates were loaded at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10,000 dilution. Predicted band size: 41 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
产品信息
PA5-116290
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 242-268 amino acids from the Central region of human PGLYRP4
偶联物
形式
Liquid
纯化类型
Protein A, Antigen affinity chromatography
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2900924
靶标信息
The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria (1, 2) and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-I beta) define a new family of human pattern recognition molecules (3). PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood (4-5).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Peptidoglycan recognition protein 4; peptidoglycan recognition protein I beta; Peptidoglycan recognition protein I-beta; Peptidoglycan recognition protein intermediate beta; peptidoglycan recognition protein-I-beta; PGLYRPIbeta; PGRP-I-beta
基因别名: PGLYRP4; PGLYRPIbeta; PGRP-Ibeta; PGRPIB; SBBI67
UniProt ID: (Human) Q96LB8
Entrez Gene ID: (Human) 57115
