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PIK3CD Antibody (PA5-15250) in ICC/IF
Immunocytochemistry analysis of PIK3CD in HeLa cells. Samples were incubated with PIK3CD polyclonal antibody (Product # PA5-15250) using a dilution of 1:25 for 1 h at 37°C followed by Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) at a dilution of 1:400 for 50 min at 37°C. Cells were fixed with 4% PFA (20 min) and permeabilized with Triton X-100 (0.1%, 10 min). Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7 units/mL, 1 h at 37°C). PI3KCD immunoreactivity is localized to Cytoplasm ... View More
产品信息
PA5-15250
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
KLH conjugated synthetic peptide between 687-717 amino acids from the C-terminal region of human PI3KCD
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Antigen affinity chromatography, Size-exclusion - Dialysis
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2237177
靶标信息
Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; phosphoinositide-3-kinase C; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; PI3-kinase p110 subunit delta; PI3-kinase subunit delta; PI3K delta; PI3K-p110delta; pi3kcd; PI3Kdelta; PI3Kp110delta; PtdIns-3-kinase subunit p110-delta
基因别名: APDS; IMD14; p110D; P110DELTA; PI3K; PIK3CD
UniProt ID: (Human) O00329
Entrez Gene ID: (Human) 5293
natural killer cell differentiation
cytokine production
adaptive immune response
mast cell chemotaxis
respiratory burst involved in defense response
protein phosphorylation
phosphatidylinositol biosynthetic process
inflammatory response
signal transduction
positive regulation of gene expression
T cell chemotaxis
phosphatidylinositol 3-kinase signaling
regulation of phosphatidylinositol 3-kinase signaling
natural killer cell activation
T cell differentiation
positive regulation of cell migration
neutrophil chemotaxis
natural killer cell chemotaxis
B cell chemotaxis
phosphatidylinositol-3-phosphate biosynthetic process
T cell activation
B cell activation
mast cell degranulation
innate immune response
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
T cell receptor signaling pathway
B cell receptor signaling pathway
mast cell differentiation
neutrophil extravasation
