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PIK3CG Antibody (PA5-102022) in IHC (P)
Immunohistochemistry analysis of PIK3CG in mouse muscle tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with PIK3CG polyclonal antibody (Product # PA5-102022) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-102022
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human PIK3CG(Accession P48736), corresponding to amino acid residues A889-T939.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
RRID
AB_2851453
产品详细信息
Antibody detects endogenous levels of total PIK3CG.
靶标信息
PIK3CG (p110 gamma) is the sole class IB phosphatidylinositol 3-kinase family member, which along with the class IA family members, generates the important second messenger PIP2. However, unlike the class IA enzymes which signal downstream of receptor tyrosine kinases, PIK3CG primarily signals downstream of GPCRs. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 1-phosphatidylinositol 3-kinase; p110-gamma; p120-PI3K; phosphatidylinositol 3 kinase gamma, p110 gamma; phosphatidylinositol 3-kinase catalytic 110-kD gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Phosphoinositide-3-kinase catalytic gamma polypeptide; phosphoinositide-3-kinase gamma catalytic subunit; PI3-kinase subunit gamma; PI3K-gamma; pi3kcg; ptdIns-3-kinase subunit gamma; PtdIns-3-kinase subunit p110-gamma; Serine/threonine protein kinase PIK3CG
基因别名: 5830428L06Rik; p110gamma; p120-PI3K; PI3CG; PI3K; Pi3kg1; PI3Kgamma; PIK3; PIK3CG
UniProt ID: (Human) P48736, (Mouse) Q9JHG7
Entrez Gene ID: (Human) 5294, (Mouse) 30955
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
1-phosphatidylinositol-3-kinase activity
phosphatidylinositol 3-kinase activity
1-phosphatidylinositol-4-phosphate 3-kinase activity
ephrin receptor binding
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
phosphotransferase activity, alcohol group as acceptor
kinase
angiogenesis
cytokine production
adaptive immune response
dendritic cell chemotaxis
positive regulation of acute inflammatory response
respiratory burst involved in defense response
protein phosphorylation
phosphatidylinositol biosynthetic process
endocytosis
inflammatory response
G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
T cell chemotaxis
negative regulation of triglyceride catabolic process
phosphatidylinositol 3-kinase signaling
platelet activation
neutrophil chemotaxis
secretory granule localization
regulation of cell adhesion mediated by integrin
natural killer cell chemotaxis
phosphatidylinositol-3-phosphate biosynthetic process
T cell proliferation
T cell activation
mast cell degranulation
positive regulation of MAP kinase activity
innate immune response
phosphatidylinositol phosphorylation
positive regulation of protein kinase B signaling
negative regulation of cardiac muscle contraction
platelet aggregation
cellular response to cAMP
neutrophil extravasation
hepatocyte apoptotic process
regulation of calcium ion transmembrane transport
negative regulation of fibroblast apoptotic process
regulation of protein phosphorylation
immune system process
chemotaxis
phosphorylation
positive regulation of catalytic activity
phosphatidylinositol-mediated signaling
