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产品信息
PA1-4515
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Reacts with residues 258-274 (YRKSKRGPKQLAPHPNI) of human PINK1
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
AB_2164245
产品详细信息
PA1-4515 detects PINK1 in human samples.
PA1-4515 has been successfully used in Western blotting procedures. By Western blot, this antibody detects a ~64 kDa protein representing PINK1 in transfected HEK293T cells.
PA1-4515 immunizing peptide corresponds to amino acid residues 258-274 of human PINK1.
靶标信息
PINK1 (PTEN-induced putative kinase 1) protects from mitochondrial dysfunction in cells by conferring different autophosphorylation activity to mitochondrial genes. The kinase domain of PINK1 appears to be critical in its protective effects. Mitochondrial proteins are critical for the regulation of cellular energy and adaptation to stress. Particularly in brain cells, mitochondrial demand is extraordinarily high, in order to accommodate aerobic and anaerobic support of high energy processes. When mitochondrial structure and/or function is disrupted in the brain, neurodegenerative diseases like Parkinson's disease are triggered.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BRPK; FLJ27236; PINK 1; PINK-1; protein kinase BRPK; PTEN-induced putative kinase protein 1; Serine/threonine-protein kinase PINK1, mitochondrial
基因别名: BRPK; PARK6; PINK1
UniProt ID: (Human) Q9BXM7
Entrez Gene ID: (Human) 65018
magnesium ion binding
protease binding
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
calcium-dependent protein kinase activity
kinase activity
peptidase activator activity
ubiquitin protein ligase binding
protein kinase B binding
C3HC4-type RING finger domain binding
non-receptor serine/threonine protein kinase
protein modifying enzyme
mitophagy
positive regulation of protein phosphorylation
regulation of oxidative phosphorylation
protein phosphorylation
ubiquitin-dependent protein catabolic process
response to stress
response to oxidative stress
mitochondrion organization
regulation of hydrogen peroxide metabolic process
negative regulation of gene expression
regulation of mitochondrion organization
positive regulation of peptidase activity
macroautophagy
positive regulation of macroautophagy
negative regulation of macroautophagy
phosphorylation
protein ubiquitination
peptidyl-serine phosphorylation
respiratory electron transport chain
regulation of protein ubiquitination
positive regulation of protein ubiquitination
activation of protein kinase B activity
positive regulation of synaptic transmission, dopaminergic
positive regulation of peptidyl-serine phosphorylation
positive regulation of dopamine secretion
cellular response to oxidative stress
positive regulation of protein dephosphorylation
intracellular signal transduction
peptidyl-serine autophosphorylation
TORC2 signaling
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of protein complex assembly
negative regulation of neuron apoptotic process
positive regulation of translation
negative regulation of JNK cascade
protein stabilization
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of ubiquitin-protein transferase activity
regulation of mitochondrial membrane potential
positive regulation of protein kinase B signaling
regulation of proteasomal protein catabolic process
cellular response to hypoxia
establishment of protein localization to mitochondrion
maintenance of protein location in mitochondrion
positive regulation of mitochondrial fission
positive regulation of release of cytochrome c from mitochondria
negative regulation of mitochondrial fission
cellular response to toxic substance
mitophagy in response to mitochondrial depolarization
regulation of synaptic vesicle transport
negative regulation of autophagosome assembly
positive regulation of mitochondrial electron transport, NADH to ubiquinone
regulation of mitophagy
negative regulation of mitophagy
negative regulation of oxidative stress-induced cell death
negative regulation of oxidative stress-induced neuron death
regulation of protein targeting to mitochondrion
negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
positive regulation of cristae formation
positive regulation of protein targeting to mitochondrion
positive regulation of free ubiquitin chain polymerization
regulation of reactive oxygen species metabolic process
negative regulation of reactive oxygen species metabolic process
positive regulation of ATP biosynthetic process
