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Invitrogen

PKC alpha/beta/gamma Recombinant Rabbit Monoclonal Antibody (24GB885)

查看其他2个PKC alpha/beta/gamma抗体
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说明书
实验方案
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产品信息

MA5-57173

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:5,000
-

免疫细胞化学 (ICC/IF)

1:100-1:1,000
-

流式细胞分析 (Flow)

1:2,000
-
产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

Expression System

HEK293F

分类

Recombinant Monoclonal

类型

Antibody

克隆号

24GB885

抗原

A synthesized peptide derived from human PKC (aa 300-500)
查看免疫原

偶联物

Unconjugated

形式

Liquid

纯化类型

Affinity chromatography

保存液

PBS, pH 7.4, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Dry ice (international)

靶标信息

Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: cAMP-dependent protein kinase catalytic subunit alpha; cAMP-dependent protein kinase catalytic subunit alpha, isoform 1; cAMP-dependent protein kinase catalytic subunit C alpha; PKA C-alpha; PKC-B; PKC-beta; PKC-gamma; protein kinase A; protein kinase A catalytic subunit; protein kinase C beta I; protein kinase C beta II; Protein kinase C beta type; protein kinase C beta-II; Protein kinase C gamma type; protein kinase C type I (gamma type); protein kinase C, beta 1; protein kinase C, beta 1 polypeptide; protein kinase C, gamma; protein kinase, cAMP-dependent, alpha catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha; sperm cAMP-dependent protein kinase catalytic subunit

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基因别名: A130082F03Rik; Cs-PKA; PKACA; PKC; PKC-Beta; PKC-gamma; PKCA1; PKCB; PKCC; PKCD; PKCG; PKCgamma; PKCI; PPNAD4; PRKACA; Prkc; PRKCB; PRKCB1; PRKCB2; Prkcc; PRKCG; RATPKCI; SCA14

UniProt ID: (Human) P17612, (Human) P05771, (Human) P05129, (Mouse) P05132, (Mouse) P68404, (Rat) P68403, (Mouse) P63318, (Rat) P63319

Entrez Gene ID: (Human) 5566, (Human) 5579, (Human) 5582, (Rat) 25636, (Mouse) 18747, (Mouse) 18751, (Rat) 25023, (Mouse) 18752, (Rat) 24681

功能
protein serine/threonine kinase activity cAMP-dependent protein kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding protein kinase binding ubiquitin protein ligase binding protein complex binding protein kinase A regulatory subunit binding chromatin binding protein kinase C activity calcium-dependent protein kinase C activity protein kinase C binding calcium channel regulator activity zinc ion binding ligand-dependent nuclear receptor transcription coactivator activity histone kinase activity (H3-T6 specific) histone binding androgen receptor binding protein kinase activity Rab GTPase binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups metal ion binding non-receptor serine/threonine protein kinase protein modifying enzyme
参与通路
G2/M transition of mitotic cell cycle mesoderm formation neural tube closure regulation of heart rate stimulatory C-type lectin receptor signaling pathway renal water homeostasis mRNA processing protein phosphorylation blood coagulation positive regulation of cell proliferation regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion peptidyl-serine phosphorylation peptidyl-threonine phosphorylation activation of protein kinase A activity calcium-mediated signaling using intracellular calcium source lipoprotein metabolic process regulation of protein binding regulation of cellular respiration regulation of osteoblast differentiation protein autophosphorylation positive regulation of protein export from nucleus sperm capacitation negative regulation of meiotic cell cycle regulation of cytosolic calcium ion concentration regulation of synaptic transmission, glutamatergic regulation of cardiac muscle contraction regulation of ryanodine-sensitive calcium-release channel activity regulation of proteasomal protein catabolic process regulation of protein processing positive regulation of cell cycle arrest cellular response to glucose stimulus cellular response to parathyroid hormone stimulus cellular response to glucagon stimulus cellular response to epinephrine stimulus cell communication by electrical coupling involved in cardiac conduction negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning regulation of cardiac conduction regulation of bicellular tight junction assembly response to hypoxia adaptive immune response transcription, DNA-templated regulation of transcription from RNA polymerase II promoter calcium ion transport cellular calcium ion homeostasis apoptotic process mitotic nuclear envelope disassembly signal transduction negative regulation of glucose transport platelet activation positive regulation of vascular endothelial growth factor receptor signaling pathway histone H3-T6 phosphorylation intracellular signal transduction B cell activation lipoprotein transport positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of angiogenesis negative regulation of insulin receptor signaling pathway B cell receptor signaling pathway positive regulation of B cell receptor signaling pathway positive regulation of NF-kappaB transcription factor activity cellular response to carbohydrate stimulus chemical synaptic transmission learning or memory chemosensory behavior phosphorylation negative regulation of protein ubiquitination regulation of response to food positive regulation of mismatch repair negative regulation of protein catabolic process regulation of circadian rhythm response to morphine negative regulation of neuron apoptotic process response to pain rhythmic process regulation of phagocytosis innervation negative regulation of proteasomal protein catabolic process modulation of synaptic transmission immune system process regulation of transcription, DNA-templated regulation of dopamine secretion chromatin modification regulation of growth response to drug response to glucose dibenzo-p-dioxin metabolic process response to vitamin D positive regulation of odontogenesis of dentin-containing tooth response to ethanol
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